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A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 αExpand
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PRDM16 controls a brown fat/skeletal muscle switch
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cellsExpand
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Transcriptional control of brown fat determination by PRDM16.
Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger proteinExpand
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, whileExpand
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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
Obesity induced in mice by high-fat feeding activates the protein kinase Cdk5 (cyclin-dependent kinase 5) in adipose tissues. This results in phosphorylation of the nuclear receptor PPARγ (peroxisomeExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; however, theExpand
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Initiation of myoblast to brown fat switch by a PRDM 16 – C / EBP-b transcriptional complex
Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a physiological defence against cold and obesity. PRDM16 (PR domain containing 16) is a 140 kDa zinc fingerExpand
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Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinctExpand
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Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex
Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a physiological defence against cold and obesity. PRDM16 (PR domain containing 16) is a 140 kDa zinc fingerExpand
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