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Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios
In the present study, the authors evaluated the diagnostic importance and the clinical significance of sperm DFI tests in infertile males with different clinical conditions.
Healthy births and ongoing pregnancies obtained by preimplantation genetic diagnosis in patients with advanced maternal age and recurrent implantation failure.
PGD should be offered to patients with advanced maternal age and those with recurrent implantation failure, as there were no significant differences between the pregnancy rates of the AMA and RIF groups (32.5 and 30% respectively).
Relationship between granular cytoplasm of oocytes and pregnancy outcome following intracytoplasmic sperm injection.
Couples with CLCG oocytes should be informed about poor on-going pregnancy rates even if fertilization, embryo quality and total pregnancy rates are normal, because a high aneuploidy rate may be linked to a high abortion rate.
Substandard application of preimplantation genetic screening may interfere with its clinical success.
In vitro Fertilization in Normoresponder Patients with Endometriomas: Comparison with Basal Simple Ovarian Cysts
- B. Kumbak, S. Kahraman, G. Karlikaya, S. Laçin, A. Guney
- MedicineGynecologic and Obstetric Investigation
- 10 December 2007
The presence of an endometriotic cyst during the IVF cycle was demonstrated to be associated with a lower embryo quality and implantation rate, although pregnancy success was unaffected.
Development and clinical application of a strategy for preimplantation genetic diagnosis of single gene disorders combined with HLA matching.
A strategy optimized for preimplantation genetic diagnosis of haemoglobinopathies combined with HLA matching and the major advantage of this approach is that the validation of a single assay can be done once and then used for the majority of the patients, reducing notably time needed for preclinical set-up of each case.
Multiple pregnancies obtained by testicular spermatid injection in combination with intracytoplasmic sperm injection.
The use of testicular spermatids in the treatment of non-obstructive azoospermia may give hope by offering a novel treatment model, but the efficiency of round sperMatids in achieving fertilization and pregnancy was disappointing.
Pregnancies achieved with testicular and ejaculated spermatozoa in combination with intracytoplasmic sperm injection in men with totally or initially immotile spermatozoa in the ejaculate.
Using testicular spermatozoa in combination with ICSI can be an alternative mode of treatment in cases with totally or initially immotile spermatoza in the ejaculate, and very low pregnancy rates have been obtained and no ongoing pregnancy has been achieved in these cases.
Fertility with testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermic men.
Although the association of TESE with ICSI obtained pregnancies for some patients with non-obstructive azoospermia, further studies are needed to determine the inclusion criteria for successful TESE, there was no statistical difference concerning the serum follicle stimulating hormone concentration, testicular volume and biopsy results in groups in which spermatozoa were obtainable or not.
Pronuclear morphology scoring and chromosomal status of embryos in severe male infertility.
Group II pre-embryos had markedly different morphology from group I, and had a low rate of blastocyst formation and high risk of chromosomally abnormal embryos, and was correlated with chromosomal complement, and impacted upon by the sperm source.