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A natural inter‐genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines
The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5′‐untranslated region (5′‐UTR)‐Core and the NS5B
RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs.
It is suggested that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C wasassociated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.
Evaluation of the HIV-1 reverse transcriptase inhibitory properties of extracts from some medicinal plants in Kenya.
Extracts from twenty two medicinal plants popularly used in preparing traditional remedies in Kenya showed at least 50 per cent reverse transcriptase inhibition, indicating that there is the probability that some antiretroviral compounds could be identified and isolated from materials from these plants.
In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine
Two compounds, K NI-227 and KNI-272, which were highly potent against HIV protease with little inhibition of other aspartic proteases, showed the most potent activity against the infectivity and cytopathic effect of a wide spectrum of HIV strains.
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.
The hypothesis that the stimulation of ddATP formation seen when ddIno is combined with ribavirin or other IMPD inhibitors is a consequence of an increased concentration of IMP, the major phosphate donor for the initial phosphorylation step in the anabolism of ddInosinate dehydrogenase to dATP is supported.
Anti‐retroviral drug resistance‐associated mutations among non‐subtype B HIV‐1‐infected Kenyan children with treatment failure
It is suggested that “vertically transmitted” primary RTI‐resistance mutations, K103N and Y181C, can persist over the years even in the absence of drug pressure and impact RTI treatment negatively, and that appearing patterns of RTi‐res resistance mutations among non‐subtype B HIV‐1‐infected children could possibly be different from those reported in subtype B‐infecting children.
Multiple routes of hepatitis C virus transmission among injection drug users in Hai Phong, Northern Vietnam
Phylogenetic analysis revealed close associations between Hai Phong strains and strains from Southern China: the Yunnan province for genotype 3b; the Guangxi province for Genotype 6e; the USA for genotypes 1a; and Southern Vietnam for genotyp 1a and 6e.
Possible HIV transmission modes among at‐risk groups at an early epidemic stage in the Philippines
The results suggest that there is potential for transmission from visa applicants to “men who have sex with men,” and that once HIV occurs in injecting drug users, it spreads rapidly among them.
Therapeutic basis of glycyrrhizin on chronic hepatitis B.