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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.
The biological functions of Runx factors in promoting cell fate determination and lineage progression are discussed, which include integrating ECM signaling and cues from developmental, hormonal, and signal transduction pathways by formation of complexes organized in subnuclear domains and mediating cell growth control. Expand
Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription
It is suggested that Src/Yes signals are integrated through organization of Runx2–YAP transcriptional complexes at subnuclear sites to attenuate skeletal gene expression. Expand
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural andExpand
Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21CIP1/WAF1 Promoter
Runx2 is identified as the first transcription factor to interact with HDAC6 and it is suggested thatHDAC6 may bind to Runx2 in differentiating osteoblasts to regulate tissue-specific gene expression. Expand
MicroRNAs 221 and 222 bypass quiescence and compromise cell survival.
The physiologic up-regulation ofmiR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coordinating competency for initiation of S phase with growth factor signaling pathways that stimulate cell proliferation. Expand
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
Runx-mediated intranuclear targeting of Smads is critical for the integration of two distinct pathways essential for fetal development. Expand
Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2
It is concluded that Runx proteins have an active role in retaining phenotype during cell division to support lineage-specific control of gene expression in progeny cells. Expand
Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.
It is shown that Runx2 is stringently regulated with respect to cell cycle entry and exit in osteoblasts and proposed that it promotes osteoblast maturation at a key developmental transition by supporting exit from the cell cycle and activating genes that facilitate bone cell phenotype development. Expand
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
It is established that mammalian Runx2 not only controls lineage commitment and cell proliferation by regulating genes transcribed by RNA Pol II, but also acts as a repressor of RNA Pol I mediated rRNA synthesis. Expand
Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
  • Je-Yong Choi, J. Pratap, +10 authors G. Stein
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 3 July 2001
It is concluded that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of RunX-dependent genes involved in tissue differentiation during embryonic development. Expand