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Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.
TLDR
In vitro results were consistent with the observation in vivo that DZP N-demethylation and S-mephenytoin 4'-hydroxylation are closely correlated in humans and suggest that the apparent discrepancy on the role of CYP forms in D ZP metabolism in vitro and in vivo may reside in the difference in substrate concentration.
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Inhibitory monoclonal antibody to human cytochrome P450 2B6.
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Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
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Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
TLDR
High-pressure liquid chromatography analysis indicated that the major metabolite of trans-7,8-diol is 7alpha,8beta-dihydroxy-9beta,10beta-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene, and the results indicate that the latter compound is metabolically formed and the major mutagenic intermediate of benzo[ a]yrene metabolism.
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Stereoselective metabolism of anthracene and phenanthrene by the fungus Cunninghamella elegans
TLDR
There are differences in both the regio- and stereoselective metabolism of anthracene and phenanthrene between the fungus C. elegans and rat liver microsomes, and the results indicate that the fungus had an S,S absolute stereochemistry.
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Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons.
  • S. K. Yang
  • Chemistry, Biology
    Biochemical pharmacology
  • 1988
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Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4.
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Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7,…
TLDR
It is suggested that it is the metabolically formed diol-epoxide that may be an ultimate carcinogenic form of benzo(a)pyrene.
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Metabolism of the mutagenic environmental pollutant, 6-nitrobenzo[a]pyrene: metabolic activation via ring oxidation.
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Enzymatic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives.
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