• Publications
  • Influence
MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis
BackgroundOocyte-derived maternal RNAs drive early embryogenesis when the newly formed embryo is transcriptionally inactive. Recent studies in zebrafish have identified the role of microRNAs duringExpand
  • 61
  • 7
Cloning and analysis of fetal ovary microRNAs in cattle.
Ovarian folliculogenesis and early embryogenesis are complex processes, which require tightly regulated expression and interaction of a multitude of genes. Small endogenous RNA molecules, termedExpand
  • 89
  • 6
Role of Importin Alpha8, a New Member of the Importin Alpha Family of Nuclear Transport Proteins, in Early Embryonic Development in Cattle1
Abstract Nuclear proteins such as transcription and chromatin remodeling factors are required for initiation of transcription in early embryos before embryonic genome activation. The nuclearExpand
  • 75
  • 6
Minimal Fertility Defects in Mice Deficient in Oocyte-Expressed Smad41
ABSTRACT Bidirectional signaling between oocytes and granulosa cells is required for normal folliculogenesis. Oocyte-secreted members of the transforming growth factor beta (TGFB) family, growthExpand
  • 58
  • 4
Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a
BackgroundNucleoplasmin 2 (NPM2) is an oocyte-specific nuclear protein essential for nuclear and nucleolar organization and early embryonic development. The aims of this study were to clone theExpand
  • 37
  • 3
Loss of Gremlin Delays Primordial Follicle Assembly but Does Not Affect Female Fertility in Mice1
ABSTRACT The transforming growth factor beta (TGFB) protein family is renowned for its diverse roles in developmental biology including reproduction. Gremlin is a member of the differentialExpand
  • 23
  • 2
Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans
Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogeneticExpand
  • 54
  • 2
  • PDF
A novel functional role for the oocyte-specific transcription factor newborn ovary homeobox (NOBOX) during early embryonic development in cattle.
Newborn ovary homeobox (NOBOX) is an oocyte-specific transcription factor essential for folliculogenesis and expression of many germ cell-specific genes in mice. Here we report the characterizationExpand
  • 36
  • 2
BMP- specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulatingExpand
  • 24
  • 2
TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis
ABSTRACT Spermiogenesis includes transcriptional silencing, chromatin condensation and extensive morphological changes as spermatids transform into sperm. Chromatin condensation involves histoneExpand
  • 16
  • 2