The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.
Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expression.
Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation
This work investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 expression in MCF‐7/adriamycin (MCF‐ 7/adr) cells.
Insulin Signaling Regulates γ-Glutamylcysteine Ligase Catalytic Subunit Expression in Primary Cultured Rat Hepatocytes
- S. K. Kim, K. Woodcroft, S. Khodadadeh, R. Novak
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2004
Insulin signaling pathways involving PI3K/Akt/p70S6K, but not MAPKs, are active in the insulin-mediated regulation of GSH synthesis via increased GCLC expression.
HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics
HepG2 cells are suggested as a cell-based model in screening for CYP inducers in drug discovery because of more similarity to human liver than the other cell lines in comparisons of the expression of cellular proteins.
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells
- Nguyen Thi Thuy Phuong, S. K. Kim, Keon Wook Kang
- BiologyBreast Cancer Research and Treatment
- 1 November 2011
Results suggest that methylation of the PTEN promoter related to both SAM increase and DNMT1 activation contributes to persistent Akt activation and are potential therapeutic targets for reversing TAM resistance in breast cancer.
Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L.
Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype.
- Su-Jin Lee, Youn-Sang Jung, Bum-Joon Park
- Biology, MedicineJournal of Clinical Investigation
- 3 October 2016
Findings indicate that specific inhibitors with the ability to block pathological progerin-lamin A/C binding may represent a promising strategy for improving lifespan and health in both HGPS and normal aging.
Age-related changes in hepatic expression and activity of cytochrome P450 in male rats
The results suggest that age-related changes in hepatic CYP isoforms may be an important factor for deciding the efficacy and safety of xenobiotics.