S. K. Kalauni

Publications44
h-index15
Citations939
Highly Influential Citations39
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Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
TLDR
Investigation of the mechanism of action of arctigenin revealed that the compound blocked the activation of Akt induced by glucose starvation, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.
Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.
TLDR
Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E showed the most potent activity with an IC50 value of 0.090 microM, more potent than the clinically used drug chloroquine (IC50, 0.29 microM).
Constituents of Caesalpinia crista from Indonesia.
TLDR
Among the isolated compounds, caesalpinin N (7) represents the first example of furanocassane-type diterpene possessing an aldehyde group at C-14, and is determined based on the spectroscopic analysis.
Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.
TLDR
The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro and norcaesalpinin E (7) showed the most potent inhibitory activity.
New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro
Two new prenylated flavones, artocarpones A and B (1 and 2), and seven known isoprenylated flavonoids, artonin A (3), cycloheterophyllin (4), artoindonesianin E (5), artoindonesianin R (6),…
Antioxidant, Phytotoxic and Antimicrobial Activities of Methanolic Extract of Bauhinia variegata Barks
TLDR
Phytochemical analysis of the extract of Bauhinia variegata revealed that the antioxidant and antimicrobial activity of the plant materials is due to the presence of active secondary metabolites.
Identification of plant extracts sensitizing breast cancer cells to TRAIL.
TLDR
Observations suggest that the identified plant extracts in combination with TRAIL could lead to potential therapeutic benefits for cancer patients in the clinical setting.
In Vitro Free Radical Scavenging Activity of Methanol Extracts of Some Selected Medicinal Plants of Nepal
TLDR
This study indicated medicinal plants in Nepal have strong antioxidant potential with high total phenolic and flavonoids content and its use in the management of diseases associated with oxidative stress is justified.
Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
TLDR
From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A and epoxysarcovagenine-D, were isolated and found to have cholinesterase inhibitory activity when tested for the inhibition of electric eel acetylcholiersterase and horse serum butyrylcholinestersterase.
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