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A new method for high-performance liquid chromatographic determination of drotaverine in plasma.
- J. Mezei, S. Küttel, P. Szentmiklosi, S. Marton, I. Rácz
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 October 1984
A sensitive, specific high-performance liquid chromatographic procedure was developed for the determination of plasma drotaverine levels and the utility of this method for determination of drotaVerine in dog and rat plasma was demonstrated. Expand
Formulation of a controlloed-release iron preparation
Laboratory-scale manufacturing method and stability test of ferrous sulphate tetrahydrate had formerly been published. Following this work, the substance was prepared on pilot-plant scale and a… Expand
[Stability tests of a new pyrido (1.2-a) pyrimidine derivative (CH-150). I. Thermal decomposition].
Pharmacokinetic study of a new 1,2,4-oxadiazine derivative in rat.
- J. Mezei, S. Küttel, I. Rácz
- Chemistry, Medicine
- Polish journal of pharmacology and pharmacy
- 1 July 1984
Plasma levels following a single oral dose of 3-phenyl-6-(1, 2, 3, 4-tetrahydro-2-isoquinolyl)-methyl-4H-5,6-dihydro -oxadiazine (I) in rat were determined by HPLC method and rate of absorption proved to be significantly higher compared to that of elimination. Expand
[In vivo and in vitro studies of the release of active ingredients in solid oral pharmaceutical preparations containing potassium chloride].
[Chemical stability of a new aryl-oxybutanol-amine cardioselective-receptor blocking agent (CH-103). I. Thermal decomposition].
High performance liquid chromatographic determination of a new biologically active 1,2,4-oxadiazine derivative in rat plasma.
A sensitive high performance liquid chromatographic procedure was developed for the determination of 3-phenyl-6-(1,2,3,4-tetrahydro-2-isoquinolyl)methyl-4H-5,6-dihydro -1, 2, 4-oxadiazine a new vasodilator, in plasma and the utility of the method for pharmacokinetic studies in the rat was demonstrated. Expand
From hit to target : identification and characterization of the 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine target in 'Trypanosoma brucei rhodesiense'
- S. Küttel
The aim was to identify and validate the target(s) of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]-morpholine (compound 1, IC ₅₀ of 1 µM on "Trypanosoma brucei rhodesiense") by the use of a chimical… Expand
[In vitro resorption study of a new anti-arrhythmia compound, N-(3,3-diphenyl-propyl)-N'-(1-phenyl-2-propyl)1,3-propylene diamine dihydrochloride].
Stability study of prostacyclin in solution.
The proton-catalyzed hydrolytic decomposition of prostacyclin was assayed by UV spectroscopic and HPLC methods and effects of alcohol and glycols on the degradation rate were studied. Expand