• Publications
  • Influence
Erythropoietin and Erythropoietin Receptor in the Developing Human Central Nervous System
We have previously shown the presence of erythropoietin (Epo) within the spinal fluid of normal preterm and term infants, and the presence of Epo receptor (Epo-R) in the spinal cords of humanExpand
  • 343
  • 10
Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus.
OBJECTIVE Erythropoietin receptors (Epo-R) have been demonstrated on several nonhematopoietic cell types in animal models and in cell culture. Our objective was to determine the tissue distributionExpand
  • 282
  • 7
Pharmacologic neuroprotective strategies in neonatal brain injury.
This article explains the mechanisms underlying choices of pharmacotherapy for hypoxic-ischemic insults of both preterm and term babies. Some preclinical data are strong enough that clinical trialsExpand
  • 73
  • 7
Origin and Fate of Erythropoietin in Human Milk
Erythropoietin (Epo) is a normal constituent of human milk, but the origin and fate of this cytokine in milk are not known. Regarding its origin, we hypothesized that cells of the mammary glandExpand
  • 81
  • 6
The Biology of Erythropoietin in the Central Nervous System and Its Neurotrophic and Neuroprotective Potential
This review summarizes published as well as preliminary data on the biology of erythropoietin (Epo) in the developing and mature human central nervous system (CNS). Both Epo receptor (Epo-R) and EpoExpand
  • 164
  • 5
Immunohistochemical Localization of Erythropoietin and Its Receptor in the Developing Human Brain
ABSTRACT We have previously shown erythropoietin (Epo) and its receptor (Epo-R) to be present in the fetal human central nervous system (CNS), and Epo to be present in the spinal fluid of normalExpand
  • 183
  • 5
Erythropoietin Concentrations in Cerebrospinal Fluid of Nonhuman Primates and Fetal Sheep following High-Dose Recombinant Erythropoietin
Erythropoietin (Epo) decreases neuronal injury and cell death in vitro and in vivo. To lay the groundwork for use of Epo as a potential therapy for brain injury, we tested the hypothesis thatExpand
  • 117
  • 5
The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
Perinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated withExpand
  • 76
  • 5
  • Open Access
High-Dose Erythropoietin Does Not Exacerbate Retinopathy of Prematurity in Rats
Preterm infants are at high risk of brain injury, and high-dose recombinant erythropoietin (rEpo) may be therapeutic. However, the effect of rEpo on the development of retinopathy of prematurityExpand
  • 28
  • 5
Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop.
HIE is not a single disease from a single cause, and is characterized by great diversity in the timing and magnitude of brain injury. It is therefore unreasonable to expect any single intervention toExpand
  • 149
  • 4
  • Open Access