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Emergence: The Connected Lives of Ants, Brains, Cities, and Software
"This book is about the mystery of why the whole is sometimes smarter than the sum of its parts."Emergence is what happens when an interconnected system of relatively simple elements self-organizesExpand
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Molecular model of a type III secretion system needle: Implications for host-cell sensing
Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens. The type III secretion system consists of cytoplasmic, transmembrane, and extracellularExpand
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A membrane-associated form of sucrose synthase and its potential role in synthesis of cellulose and callose in plants.
Sucrose synthase (SuSy; EC; sucrose + UDP reversible UDPglucose + fructose) has always been studied as a cytoplasmic enzyme in plant cells where it serves to degrade sucrose and provideExpand
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Self-chaperoning of the Type III Secretion System Needle Tip Proteins IpaD and BipD*
Bacteria expressing type III secretion systems (T3SS) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever.Expand
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Architecture of the major component of the type III secretion system export apparatus
Type III secretion systems (T3SSs) are bacterial membrane–embedded nanomachines designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion through T3SS is governed by aExpand
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Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. InExpand
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Interface Culture: How New Technology Transforms the Way We Create and Communicate
From the Publisher: Steven Johnson bridges the gap that yawns between technology and the arts. Drawing on his own expertise in the humanities and on the Web, he not only demonstrates how interfacesExpand
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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain aExpand
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Dimerization of complement factor H-related proteins modulates complement activation in vivo
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within theExpand
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What's the point of the type III secretion system needle?
Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretionExpand
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