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Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.
BACKGROUND Alzheimer's disease is characterized by amyloid-beta plaques, neurofibrillary tangles, gliosis, and neuronal loss. Solanezumab, a humanized monoclonal antibody, preferentially bindsExpand
Quality of informed consent: a new measure of understanding among research subjects.
BACKGROUND The informed consent of participants is ethically and legally required for most research involving human subjects. However, standardized methods for assessing the adequacy of informedExpand
Quality of informed consent in cancer clinical trials: a cross-sectional survey
BACKGROUND Investigators have to obtain informed consent before enrolling participants in clinical trials. We wanted to measure the quality of understanding among participants in clinical trials ofExpand
Whole-exome sequencing and clinical interpretation of formalin-fixed , paraffin-embedded tumor samples to guide precision cancer medicine
682 VOLUME 20 | NUMBER 6 | JUNE 2014 naTuRe medicine Translating whole-exome sequencing (WES) for prospective clinical use may have an impact on the care of patients with cancer; however, multipleExpand
Actionable exomic incidental findings in 6503 participants: challenges of variant classification.
Recommendations for laboratories to report incidental findings from genomic tests have stimulated interest in such results. In order to investigate the criteria and processes for assigning theExpand
Comparison of outcomes in cancer patients treated within and outside clinical trials: conceptual framework and structured review
BACKGROUND Many oncologists believe that patients with cancer who enroll in clinical trials have better outcomes than those who do not enroll. We aimed to assess the empirical evidence that such aExpand
A phase 3 trial of semagacestat for treatment of Alzheimer's disease.
BACKGROUND Alzheimer's disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase on amyloidExpand
Clinical Trials and Medical Care: Defining the Therapeutic Misconception
A key component of informed consent to participate in medical research includes understanding that research is not the same as treatment.
Incidental Findings in Human Subjects Research: What Do Investigators Owe Research Participants?
The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental findings discovered in the course of research. InExpand
Patient Perspectives on the Learning Health System: The Importance of Trust and Shared Decision Making
We conducted focus groups to assess patient attitudes toward research on medical practices in the context of usual care. We found that patients focus on the implications of this research for theirExpand