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Widespread Sexual Disruption in Wild Fish
This paper demonstrates a high incidence of intersexuality in wild populations of riverine fish (roach; Rutilus rutilus) throughout the United Kingdom and indicates that reproductive and developmental effects do result from exposure to ambient levels of chemicals present in typical British rivers. Expand
Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment.
It is found that effluent from sewage treatment works contains a chemical, or mixture of chemicals, that induces vitellogenin synthesis in male fish maintained in the effluent, thus indicating that the effluents is estrogenic. Expand
Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals
Exposure of male rainbow trout to four different alkylphenolic chemicals caused synthesis of vitellogenin, a process normally dependent on endogenous estrogens, and a concomitant inhibition of testicular growth, support the contention that exposure of wildlife to environmentally persistent estrogenic chemicals can result in deleterious reproductive consequences. Expand
Environmentally persistent alkylphenolic compounds are estrogenic.
It is shown that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals and capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines. Expand
Endocrine disruption in wildlife: a critical review of the evidence.
The evidence, from both laboratory and field studies, that exposure to steroid hormone mimics may impair reproductive function is reviewed and the weight of evidence for endocrine disruption in wildlife is critically assessed. Expand
State of the Science of Endocrine Disrupting Chemicals - 2012
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of UNEP or WHO concerning the legal status of anyExpand
Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes
Abstract Alkylphenol-polyethoxylates (APnEO, n = 1–40) are a major group of surfactants and are normally present in raw sewage. Many of the products of the biodegradation of these compounds are bothExpand
A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic.
The current finding that some phthalate compounds and some food additives are weakly estrogenic in vitro, needs to be supported by further studies on their effects in vivo before any conclusions can be made regarding their possible role in the development of these conditions. Expand
An ecological assessment of bisphenol-A: evidence from comparative biology.
A comparison of measured BPA environmental concentrations with chronic values suggests that no significant margin of safety exists for the protection of aquatic communities against the toxicity of BPA. Expand
Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout
It was recently demonstrated that most, if not all, effluents of sewage-treatment works (STWs) in the United Kingdom are estrogenic to fish. As many STWs discharge into rivers, it is possible thatExpand