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Heterochromatin revisited
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a modelExpand
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the purification of an RNAi effector complex termedExpand
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RITS acts in cis to promote RNA interference–mediated transcriptional and post-transcriptional silencing
RNA interference is a conserved mechanism by which double-stranded RNA is processed into short interfering RNAs (siRNAs) that can trigger both post-transcriptional and transcriptional gene silencing.Expand
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RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins
At the silent mating-type interval of fission yeast, the RNA interference (RNAi) machinery cooperates with cenH, a DNA element homologous to centromeric repeats, to initiate heterochromatinExpand
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Csi1 links centromeres to the nuclear envelope for centromere clustering
Csi1 promotes centromere clustering by linking centromeres to the SUN domain protein Sad1 in the nuclear envelope.
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Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin
In eukaryotes, heterochromatin mediates diverse processes including gene silencing and regulation of long-range chromatin interactions. The formation of heterochromatin involves a conserved array ofExpand
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Histone H3 Lysine 14 Acetylation Is Required for Activation of a DNA Damage Checkpoint in Fission Yeast*
Background: Histone acetylation regulates diverse cellular processes. Results: The fission yeast Mst2 complex is a specific histone H3 lysine 14 acetyltransferase. Conclusion: H3K14 acetylation isExpand
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Heterochromatin Regulates Cell Type-Specific Long-Range Chromatin Interactions Essential for Directed Recombination
Mating-type switching in Schizosaccharomyces pombe involves replacing genetic information at the expressed mat1 locus with sequences copied from one of two silent donor loci, mat2-P or mat3-M,Expand
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Rapid epigenetic adaptation to uncontrolled heterochromatin spreading
Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.Expand
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The proper connection between shelterin components is required for telomeric heterochromatin assembly.
Telomeric regions contain prominent sites of heterochromatin, which is associated with unique histone modification profiles such as the methylation of histone H3 at Lys9 (H3K9me). In fission yeast,Expand
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