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New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus.
Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophile and showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.
Effects of three diterpenoids on tumour cell proliferation and telomerase activity
- Yunshan Yang, Handong Sun, Yiping Zhou, S. Ji, M. Li
- Chemistry, BiologyNatural product research
- 20 July 2009
It is found that XB, MB and EB could significantly inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs.
[Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln[ (Phen)2 (5-Fu)3 (NO3) (NO3 )2].
- Wenmin Zhong, Zhi-xing Hu, Shunshun Chen, S. Ji, Yi-ping Zhou, M. Li
- Chemistry, BiologyYao xue xue bao = Acta pharmaceutica Sinica
- 1 November 2005
The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro, and might have anti-Tumor cooperation action.