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New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus.
TLDR
Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophile and showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.
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Effects of three diterpenoids on tumour cell proliferation and telomerase activity
TLDR
It is found that XB, MB and EB could significantly inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs.
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[Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln[ (Phen)2 (5-Fu)3 (NO3) (NO3 )2].
TLDR
The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro, and might have anti-Tumor cooperation action.
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