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Milestones of neuronal development in the adult hippocampus
Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between theseExpand
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A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Neurogenesis and Spatial Memory The dentate gyrus of the hippocampus is one of two sites in the brain where new neurons are produced throughout life. Adult-born neurons integrate into the dentateExpand
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Wnt signalling regulates adult hippocampal neurogenesis
The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranularExpand
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Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
To study how adult hippocampal neurogenesis might originate from the proliferation of stem or progenitor cells in vivo, we have used transgenic mice expressing green fluorescent protein (GFP) underExpand
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Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules that modulate their quiescence are largely unknown. Here, we show that bone morphogenetic protein (BMP)Expand
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Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling
Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used toExpand
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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson'sExpand
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Adult neurogenesis
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Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
In adult hippocampal neurogenesis, new neurons appear to originate from a cell with astrocytic properties expressing glial fibrillary acidic protein (GFAP). Also, new astrocytes are generated in theExpand
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Adult‐born hippocampal neurons mature into activity‐dependent responsiveness
The mammalian hippocampus is a highly plastic brain structure in which new neurons are generated throughout adulthood. Do these new neurons qualitatively and quantitatively participate in theExpand
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