• Publications
  • Influence
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnosticExpand
  • 1,214
  • 102
Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients
BackgroundThe diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied.Expand
  • 409
  • 19
Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica
Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a distinct diseaseExpand
  • 278
  • 18
Characteristics of Susac syndrome: a review of all reported cases
In Susac syndrome, occlusions of microvessels—presumed to be mediated by an autoimmune response to an as yet unknown antigen—lead to a characteristic clinical triad of CNS dysfunction, branch retinalExpand
  • 172
  • 17
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
BackgroundA subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG).ObjectiveTo describeExpand
  • 317
  • 16
Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis.
BACKGROUND There is increasing recognition of antibody-mediated immunotherapy-responsive neurologic diseases and a need for appropriate immunoassays. OBJECTIVES To develop a clinically applicableExpand
  • 262
  • 16
Antibody to aquaporin-4 in the long-term course of neuromyelitis optica
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly specific serumExpand
  • 355
  • 15
Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)
Abstract Neuromyelitis optica (NMO, Devic’s syndrome), long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity. Major progress has been made in theExpand
  • 334
  • 13
Neuromyelitis optica: clinical features, immunopathogenesis and treatment
The term ‘neuromyelitis optica’ (‘Devic's syndrome’, NMO) refers to a syndrome characterized by optic neuritis and myelitis. In recent years, the condition has raised enormous interest amongExpand
  • 178
  • 13
Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance
BackgroundIn 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests thatExpand
  • 146
  • 13