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Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia
- O. Orzylowska, B. Oderfeld-Nowak, M. Zaremba, S. Januszewski, M. Mossakowski
- Neuroscience Letters
- 1 March 1999
We have investigated the pattern of expression of IL-1beta and IL-6 immunoreactivities in rat hippocampus after transient complete brain ischemia evoked by a 10 min cardiac arrest, at survival times… Expand
Synaptosomal susceptibility on global ischaemia caused by cardiac arrest correlated with early and late times after recirculation in rats.
- G. Sulkowski, J. Waśkiewicz, M. Walski, S. Januszewski, U. Rafałowska
- 1 February 2002
The aim of the study was to assess the sensitivity of brain synaptosomes and their mitochondria to the effects of global cerebral ischaemia caused by temporary cardiac arrest and the early and late… Expand
Evidence of blood‐brain barrier permeability/leakage for circulating human Alzheimer's β‐amyloid‐(1–42)‐peptide
BRAINS from patients with Alzheimer's disease contain amyloid plaques which are composed of β-amyloid peptide and are considered to play a causal role in the neuropathology of this disease. The… Expand
Platelets, lymphocytes and erythrocytes from Alzheimer's disease patients: the quest for blood cell-based biomarkers.
- R. Pluta, Marzena Ułamek-Kozioł, S. Januszewski, S. Czuczwar
- Biology, Medicine
- Folia neuropathologica
In elderly population, Alzheimer's disease is a common neurodegenerative disorder and accounts for about 70% of all cases of dementia. The neurodegenerative processes of this disease start presumably… Expand
One year follow up in ischemic brain injury and the role of Alzheimer factors.
Ongoing interest in brain ischemia research has provided data showing that ischemia may be involved in the pathogenesis of Alzheimer disease. Brain ischemia in the rat produces a stereotyped pattern… Expand
Autophagy, mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer's disease.
- Marzena Ułamek-Kozioł, J. Kocki, +4 authors R. Pluta
- Pharmacological reports : PR
- 1 December 2017
BACKGROUND Postichemic brain injury correlates with poor prognosis since selectively vulnerable parts of brain are associated with apoptotic neuronal death. But autophagy has been recognized, as a… Expand
Ischemic blood-brain barrier and amyloid in white matter as etiological factors in leukoaraiosis.
BACKGROUND Pathology of white matter, which is observed in ischemic brain, indicates that similar processes contribute to Alzheimer's disease development. These injuries have been seen in the… Expand
Dysregulation of Autophagy, Mitophagy, and Apoptotic Genes in the Medial Temporal Lobe Cortex in an Ischemic Model of Alzheimer’s Disease
- Marzena Ułamek-Kozioł, J. Kocki, +9 authors R. Pluta
- Medicine, Biology
- Journal of Alzheimer's disease : JAD
- 27 July 2016
Ischemic brain damage is a pathological incident that is often linked with medial temporal lobe cortex injury and finally its atrophy. Post-ischemic brain injury associates with poor prognosis since… Expand
Exosomes as possible spread factor and potential biomarkers in Alzheimer's disease: current concepts
Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes
- R. Pluta, M. Jablonski, +7 authors S. Czuczwar
- Psychology, Medicine
- Molecular Neurobiology
- 22 March 2013
The study of sporadic Alzheimer’s disease etiology, now more than ever, needs an infusion of new concepts. Despite ongoing interest in Alzheimer’s disease, the basis of this entity is not yet clear.… Expand