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Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator.
- Byung-Min Choi, H. Pae, S. Jang, Y. Kim, Hun-taeg Chung
- Biology, Medicine
- Journal of biochemistry and molecular biology
- 31 January 2002
The current understanding of the mechanisms by which NO exerts both pro- and anti-apoptotic action is discussed in this review article. Expand
Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.
- S. Jang, H. J. Kim, Young-jun Kim, Seung-Il Jeong, Y. You
- Chemistry, Medicine
- European journal of pharmacology
- 7 August 2006
Tanshinone IIA may inhibit LPS-induced IkappaB alpha degradation and NF-kappaB activation via suppression of the NIK-IKK pathway as well as the MAPKs (p38, ERK1/2, and JNK) pathway in RAW 264.7 cells and these properties may provide a potential mechanism that explains the anti-inflammatory activity of tanshin one IIA. Expand
Tanshinone IIA from Salvia miltiorrhiza Inhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells
The results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1beta,IL-6 and TNF-alpha production, and expression of iNOS. Expand
Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.
Results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression. Expand
Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression.
- Bok-Soo Lee, S. Shim, +6 authors Hun-taeg Chung
- Biology, Medicine
- Journal of dermatological science
- 1 April 2007
Wogonin induces HO1 expression, which in turn HO1 and/or CO suppresses TARC expression induced by mite antigen in human HaCaT cells, suggesting a direct role of HO1 for the suppressive effect. Expand
Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages
- B. Cho, H. Yin, S. H. Park, Eui-Baek Byun, Hun-Yong Ha, S. Jang
- Chemistry, Medicine
- Bioscience, biotechnology, and biochemistry
- 12 April 2016
It is suggested that myricetin inhibits the production of pro-inflammatory mediators through the suppression of NF-κB and STAT1 activation and induction of Nrf2-mediated HO-1 expression in LPS-stimulated RAW264.7 macrophages. Expand
Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells.
Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), was found to induce apoptosis in human promyelocytic leukaemia, HL-60 cells and the cytochrome c/caspase-9 pathway was responsible for imperatorin-induced apoptosis. Expand
Inhibitory effects of the stem bark of Catalpa ovata G. Don. (Bignoniaceae) on the productions of tumor necrosis factor-alpha and nitric oxide by the lipopolisaccharide-stimulated RAW 264.7…
The methanol extract of Catalpa ovata stem bark inhibited the productions of TNF-alpha and NO with significant decreases in mRNA levels of TNI and inducible NO synthase, suggesting that the stem bark of Catalonia ovata may have therapeutic potential in the control of inflammatory disorders. Expand
Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves
Luteolin has potential as a therapeutic agent against inflammation and itch-related skin diseases and significantly reduced the histamine release from rat peritoneal mast cells stimulated by compound 48/80, a potent histamine liberator. Expand
Inhibition of TNF-α, IL-1β, and IL-6 productions and NF-κB activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don…
Flow cytometric analysis revealed that catalposide suppressed the binding of FITC-conjugated LPS to CD14 on the surface of cells, probably resulting in the inhibitory effects on TNF-α, IL-1β, and IL-6 productions and NF-κB activation. Expand