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Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
Parkinson's disease (PD; OMIM #168600) is the second most common neurodegenerative disorder in the Western world and presents as a progressive movement disorder. The hallmark pathological features ofExpand
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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinaseExpand
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The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation*
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. ItExpand
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The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the leading genetic cause of Parkinson's disease (PD). LRRK2 is predicted to contain kinase and GTPase enzymatic domains, with recent evidenceExpand
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High Content Screening in Neurodegenerative Diseases
The functional annotation of genomes, construction of molecular networks and novel drug target identification, are important challenges that need to be addressed as a matter of great urgency1-4.Expand
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Kinetic modeling of ATP synthesis by ATP synthase and its mechanistic implications.
  • S. Nath, S. Jain
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 16 June 2000
Based on the torsional mechanism of ATP synthesis by ATP synthase, a kinetic scheme has been developed in this work. The scheme considers adenine nucleotide transport, binding of substrates ADP andExpand
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From Single Genes to Gene Networks: High-Throughput-High-Content Screening for Neurological Disease
Neuronal development, function, and the subsequent degeneration of the brain are still an enigma in both the normal and pathologic states, and there is an urgent need to find better targets forExpand
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SFRS7-Mediated Splicing of Tau Exon 10 Is Directly Regulated by STOX1A in Glial Cells
Background In this study, we performed a genome-wide search for effector genes bound by STOX1A, a winged helix transcription factor recently demonstrated to be involved in late onset Alzheimer'sExpand
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The Complete Automation of Cell Culture
Genomic approaches provide enormous amounts of raw data with regard to genetic variation, the diversity of RNA species, and protein complement. High-throughput (HT) and high-content (HC) cellularExpand
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