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Establishing, maintaining and modifying DNA methylation patterns in plants and animals
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. RecentExpand
Genetic and Functional Diversification of Small RNA Pathways in Plants
Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and short interfering RNA (siRNA). They collectively function asExpand
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning
Cytosine DNA methylation is important in regulating gene expression and in silencing transposons and other repetitive sequences. Recent genomic studies in Arabidopsis thaliana have revealed that manyExpand
Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis
Cytosine methylation is important for transposon silencing and epigenetic regulation of endogenous genes, although the extent to which this DNA modification functions to regulate the genome is stillExpand
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis
Trimethylation of histone H3 lysine 27 (H3K27me3) plays critical roles in regulating animal development, and in several cases, H3K27me3 is also required for the proper expression of developmentallyExpand
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Summary Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in differentExpand
Criteria for Annotation of Plant MicroRNAs
MicroRNAs (miRNAs) are ∼21 nucleotide noncoding RNAs produced by Dicer-catalyzed excision from stem-loop precursors. Many plant miRNAs play critical roles in development, nutrient homeostasis,Expand
UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
Epigenetic inheritance in mammals relies in part on robust propagation of DNA methylation patterns throughout development. We show that the protein UHRF1 (ubiquitin-like, containing PHD and RINGExpand
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
Gene silencing in eukaryotes is associated with the formation of heterochromatin, a complex of proteins and DNA that block transcription. Heterochromatin is characterized by the methylation ofExpand
Conservation and divergence of methylation patterning in plants and animals
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. Although DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNAExpand