• Publications
  • Influence
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Defects in iron absorption and utilization lead to iron deficiency and overload disorders. Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through placental transport.Expand
  • 1,439
  • 67
The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis.
In vertebrates, hematopoietic and vascular progenitors develop from ventral mesoderm. The first primitive wave of hematopoiesis yields embryonic red blood cells, whereas progenitor cells ofExpand
  • 498
  • 40
Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme.
Mammalian lung develops as an evagination of ventral gut endoderm into the underlying mesenchyme. Iterative epithelial branching, regulated by the surrounding mesenchyme, generates an elaborateExpand
  • 317
  • 21
  • PDF
Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell
The relative roles of the Kit receptor in promoting the migration and survival of amniote melanocytes are unresolved. We show that, in the zebrafish, Danio rerio, the pigment pattern mutation sparseExpand
  • 291
  • 20
  • PDF
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remainsExpand
  • 358
  • 15
The zebrafish klf gene family.
The Krüppel-like factor (KLF) family of genes encodes transcriptional regulatory proteins that play roles in differentiation of a diverse set of cells in mammals. For instance, the founding memberExpand
  • 107
  • 12
  • PDF
Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1‐deficient human cell line
Transcription factors of the STAT family are required for cellular responses to multiple signaling molecules. After ligand binding‐induced activation of cognate receptors, STAT proteins areExpand
  • 123
  • 9
  • PDF
Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis.
Members of the JAK family of protein tyrosine kinase (PTK) proteins are required for the transmission of signals from a variety of cell surface receptors, particularly those of the cytokine receptorExpand
  • 87
  • 5
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia
Many human anaemias are caused by defects in haemoglobin synthesis. The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemoglobin production is perturbed.Expand
  • 229
  • 4
Fumigant Toxicity of Essential Oils and Monoterpenes Against the Red Flour Beetle, Tribolium castaneum Herbst
Abstract Toxicity of various essential oils and their volatile components against the red flour beetle, Tribolium castaneum (Herbst) was determined. The most potent fumigant toxicity was found inExpand
  • 87
  • 4