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Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether smallExpand
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.
Evidence is presented that type IV pili, flagellum-mediated motility and quorum sensing-controlled DNA release are involved in the formation of mature multicellular structures in P. aeruginosa biofilms. Expand
Nasal microenvironments and interspecific interactions influence nasal microbiota complexity and S. aureus carriage.
Spatial variation in nasal microbial communities and differences in community composition between S. aureus carriers and noncarriers are highlighted. Expand
Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus.
It is demonstrated that inactivation of Spx in the important pathogen Staphylococcus aureus renders the cells hypersensitive to a wide range of stress conditions including high and low temperature, high osmolarity, and hydrogen peroxide, and it is concluded that Spx fulfills an important role for growth, general stress protection, and biofilm formation in S. a Aureus. Expand
Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa.
Genetic evidence is presented that during biofilm development by P. aeruginosa, biosurfactants promote microcolony formation in the initial phase and facilitate migration-dependent structural development in the later phase of biofilm formation. Expand
An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal.
The molecular mechanisms underlying the tolerance of biofilm bacteria to antimicrobial agents are beginning to be unraveled, and new knowledge has been obtained regarding the environmental cues and regulatory mechanisms involved in biofilm dispersal. Expand
Insight into the microbial multicellular lifestyle via flow‐cell technology and confocal microscopy
The molecular mechanisms underlying the increased tolerance that biofilm cells often display towards antibiotic treatment are beginning to be unravelled. Expand
Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries
The total acquired AMR level was associated with the overall country-specific antimicrobial usage in livestock and that countries with comparable usage patterns had similar resistomes, however, functionally determined AMR genes were not associated with total drug use. Expand
Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).
Four ADP-ribosyltransferase sequence types, and a myosin-cross-reactive antigen (MCRA) protein were discovered; it is hypothesize that they are involved in modulation of host responses. Expand
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
The model that rhamnolipids are key protective agents of P. aeruginosa against PMNs is supported, as the experimental data showed that an inactivating mutation in the single QS‐controlled rhlA gene did not induce necrosis of PMNs in vitro and exhibited increased clearance compared with its wild‐type counterpart in vivo. Expand