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Recognition of an Essential Adenine at a Protein−RNA Interface: Comparison of the Contributions of Hydrogen Bonds and a Stacking Interaction
The energetic contribution of stacking interactions to the stabilization of protein-nucleic acid complexes is not well established.1 Stacking interactions between proteins and nucleic acid helices… Expand
Investigation of a conserved stacking interaction in target site recognition by the U1A protein.
- J. Shiels, Jacob B Tuite, S. J. Nolan, A. Baranger
- Biology, Medicine
- Nucleic acids research
- 15 January 2002
These experiments suggest that Phe56 contributes to binding affinity by stacking with A6 and participating in networks of energetically coupled interactions that enable this conserved aromatic amino acid to play a complex role in target site recognition. Expand
Solution properties and computational analysis of an oligodeoxynucleotide containing N-(deoxyguanosin-8-yl)-1-aminopyrene.
The C8-guanine adduct of aminopyrene thus appears to perturb the B-DNA structure to a greater extent than do the adducts of less bulky amines such as aminofluorene and 4-aminobiphenyl. Expand
Synthesis and characterization of oligodeoxynucleotides containing N-(deoxyguanosin-8-yl)-1-aminopyrene
Oligodeoxynucleotides containing N-(deoxyguanosin-8-yl)-1-aminopyrene, the major DNA adduct formed by 1-nitropyrene in vivo, were synthesized in 10–20% yield by reacting N-hydroxy-1-aminopyrene with… Expand
C8-guanine adduct-induced stabilization of a -1 frame shift intermediate in a nonrepetitive DNA sequence.
- S. J. Nolan, J. McNulty, R. Krishnasamy, W. Mcgregor, A. Basu
- Biology, Medicine
- 23 September 1999
A relationship between the thermodynamic stability of the adduct in DNA and the errors that occurred during replicative bypass by the human DNA polymerases is suggested. Expand