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Synaptic plasticity and memory: an evaluation of the hypothesis.
Changing the strength of connections between neurons is widely assumed to be the mechanism by which memory traces are encoded and stored in the central nervous system. In its most general form, theExpand
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Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory.
TLDR
We propose a neurobiological theory of hippocampal (HPC) function in which activity-dependent synaptic plasticity, such as long-term potentiation, plays a key part in the forms of memory mediated by this brain structure. Expand
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An Evaluation of the Hypothesis
Changing the strength of connections between neurons is widely assumed to be the mechanism by which memory traces are encoded and stored in the central nervous system. In its most general form, theExpand
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Synaptic tagging and capture in the living rat
In isolated hippocampal slices, decaying long-term potentiation (LTP) can be stabilized, and converted to late-LTP lasting many hours, by prior or subsequent strong high-frequency tetanization of anExpand
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Audiovisual Distraction Increases Prefrontal Cortical Neuronal Activity and Impairs Attentional Performance in the Rat
Involvement of attentional processes is generally evidenced by disruption of behavior in the presence of distracting stimuli. The medial prefrontal cortex (mPFC) seems to play a role in fine-tuningExpand
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Effect of Certain Endocrine Secretions on the × Zone of the Adrenal Cortex of the Mouse.∗
The discovery of a sex dimorphism in the adrenal cortex of the young mouse 1 and its relation to age and sex 2 suggests that this structure is influenced by certain endocrine secretions. TheExpand
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Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats
What We Already Know about This Topic Cognitive capabilities may be impaired in the postoperative period Impaired cognition may affect the patient’s ability to perform activities of daily living WhatExpand
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Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats.
Pain alters cognitive performance through centrally mediated effects in the brain. In this study, we hypothesized that persistent activation of peripheral nociceptors after injury would lead to theExpand
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Formation of a morphine-conditioned place preference does not change the size of evoked potentials in the ventral hippocampus–nucleus accumbens projection
In opioid addiction, cues and contexts associated with drug reward can be powerful triggers for drug craving and relapse. The synapses linking ventral hippocampal outputs to medium spiny neurons ofExpand
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