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Neuroprotective effects of group III mGluR in traumatic neuronal injury.
We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial… Expand
New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity.
The multiplicity and complexity of secondary injury processes following brain trauma in vivo make it difficult to elucidate the roles of specific injury mechanisms. As with other areas of CNS injury,… Expand
New insights into the mechanism of drug-induced dyskinesia
Dyskinesia is an extrapyramidal movement disorder characterized by involuntary, repetitive, irregular motions that affect the mouth and face and/or the limbs and trunk. Tardive dyskinesia (TD) is a… Expand
Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia
- A. F. Y. A. Hadithy, S. Ivanova, P. Pechlivanoglou, A. Semke, A. Loonen
- Psychology, Medicine
- Progress in Neuro-Psychopharmacology and…
- 30 April 2009
BACKGROUND Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians. PURPOSE To… Expand
Missense polymorphisms in three oxidative‐stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia
Neuronal degeneration due to oxidative stress (OS) has been proposed as a mechanism for tardive dyskinesia (TD) pathogenesis. Cellular defense mechanisms against OS may involve detoxification enzymes… Expand
Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine.
BACKGROUND Schizophrenia is a psychiatric disorder that affects approximately 0.4%-1% of the population worldwide. Diagnosis of schizophrenia is based primarily on Diagnostic and Statistical Manual… Expand
ROLE OF 5-HT2C RECEPTORS IN DYSKINESIA
By integrating knowledge gained by pharmacogenetic, neuroanatomical and pharmacological studies, a model can be constructed how serotonin (5-HT) affects the vulnerability to induce tardive… Expand
Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury.
- J. Allen, S. Ivanova, L. Fan, M. Espey, A. Basile, A. Faden
- Biology, Medicine
- The Journal of pharmacology and experimental…
- 1 July 1999
We examined the effects of modulating group II metabotropic glutamate receptors (mGluRs) on traumatic neuronal injury using both in vitro and in vivo models. Treatment with various selective group II… Expand
mGluR modulation of post‐traumatic neuronal death: role of NMDA receptors
THE potential interaction between group I metabotropic glutamate receptors (mGluR) and NMDA receptors in mediating of post-traumatic neuronal death was studied using an in vitro trauma model.… Expand
Use of Carnosine for Oxidative Stress Reduction in Different Pathologies
- V. D. Prokopieva, E. Yarygina, N. Bokhan, S. Ivanova
- Medicine, Chemistry
- Oxidative medicine and cellular longevity
- 24 January 2016
The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies… Expand