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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9. Expand
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory. Expand
Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory andExpand
Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation
The authors' data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and, furthermore, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice. Expand
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
It is indicated that cortical NMDARs are essential for the aggregation of layer IV cells into barrels and for development of the full complement of thalamocortical patterns. Expand
The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis
It is shown that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 and vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. Expand
Innate versus learned odour processing in the mouse olfactory bulb
It is shown that, in dorsal-zone-depleted mice, the dorsal domain of the olfactory bulb was devoid of glomerular structures, although second-order neurons were present in the vacant areas, which indicates that aversive information is received in the ofactory bulb by separate sets ofglomeruli, those dedicated for innate and those for learned responses. Expand
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
It is shown that the conditional deletion of the small Rho-GTPase cdc42 at different stages of neurogenesis in mouse telencephalon results in an immediate increase in basal mitoses, thereby regulating the position of mitoses and cell fate. Expand
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+Expand