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Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system
- H. Harada, E. Takahashi, S. Itoh, K. Harada, T. Hori, T. Taniguchi
- BiologyMolecular and cellular biology
- 1 February 1994
Interestingly, one IRF binding site was found within the IRF-2 promoter, and expression of the IRf-2 gene was affected by both transient and stableIRF-1 expression, which may shed light on the complex gene network involved in regulation of the IFN system.
Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.
- G. Yamada, M. Ogawa, T. Taniguchi
- BiologyProceedings of the National Academy of Sciences…
- 15 January 1991
Transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer are generated and it is indicated that the bone marrow is the effective site for specific depletion of the B-cell population.
Transient induction of IL‐2 receptor in cultured T cell lines by HTLV‐1 LTR‐linked tax‐1 gene.
The experimental data suggest that the observed heterogeneity in IL‐2R alpha expression in the transformants is due to a cell‐cycle‐regulated expression and function of tax‐1.
Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31.
Priming for in vitro and in vivo anti-human T lymphotropic virus type 1 cellular immunity by virus-related protein reconstituted into liposome.
Exogenous protein reconstituted into appropriate liposomes can effectively prime MHC class I restricted CD8+ T cells in vivo with macrophage dependency, indicating the necessity of macrophages for priming of CD8 + T cells with gag-env-lipo.
Sequence of a cDNA coding for human IRF-2.
A cDNA coding for human IRF-2 is isolated by crosshybridization with the mouse IRf-2 full length cDNA probe, using the human T cell line, Jurkat-111 cDNA library, and one of the positive clones, pfflRF4S-51, was sequenced.
Immobilized antibody-based flow type enzyme immunosensor for determination of human serum albumin
A System-Biological Approach to Interferon-Based Therapies
A system-biological approach is shown to figure out the intracellular system activated in the IFN-based therapies and it would be useful for improvement in the efficacy of theIFN- based therapies and personalized therapies.