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Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli.
OBJECTIVE The aim was to determine whether left ventricular apical myocardium has mechanisms to compensate for sparse sympathetic innervation. METHODS Contractile and metabolic responses to variousExpand
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Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195
Aims/hypothesis. Advanced glycation end products (AGEs) participate in the pathogenesis of diabetic nephropathy. We reported earlier that OPB-9195, a synthetic thiazolidine derivative and novelExpand
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Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin‐1‐induced contraction in human bronchi
1 Endothelin (ET)‐1 has been postulated to be involved in the development of obstructive airway diseases in man. In the present study, we attempted to characterize ET receptor subtypes mediatingExpand
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Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes.
There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulatingExpand
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Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats.
The present study was undertaken to determine whether a non-peptide arginine vasopressin (AVP) antagonist [5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra hydro-1H- benzazepine]Expand
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Increases in interleukin-6 and matrix metalloproteinase-9 in the infarct-related coronary artery of acute myocardial infarction.
BACKGROUND To elucidate the involvement of inflammation in coronary artery occlusion, the regional changes in cytokines and matrix metalloproteinases (MMPs) in the infarct-related coronary arteryExpand
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Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng).
The antitumor activity of the crude water extract from Gac fruit (Momordica cochinchinensis) was investigated in vivo and in vitro. A water extract prepared from 0.75 and 0.25 mg dry weight of GacExpand
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Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats.
The present study was undertaken to determine whether the non-peptide V2 antidiuretic hormone (ADH) antagonist 5-dimethylamino-1[4-(2- methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepineExpand
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Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats.
Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats. Isolated glucocorticoid and mineralocorticoid deficiency have been known toExpand
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Association of Hyperadiponectinemia With Severity of Ventricular Dysfunction in Congestive Heart Failure
Background Adiponectin, which is a collagen-like plasma protein produced by adipose tissue, has anti-atherogenic and anti-inflammatory effects. Plasma adiponectin levels in patients with congestiveExpand
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