Author pages are created from data sourced from our academic publisher partnerships and public sources.
Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli.
OBJECTIVE The aim was to determine whether left ventricular apical myocardium has mechanisms to compensate for sparse sympathetic innervation. METHODS Contractile and metabolic responses to various… Expand
Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195
Aims/hypothesis. Advanced glycation end products (AGEs) participate in the pathogenesis of diabetic nephropathy. We reported earlier that OPB-9195, a synthetic thiazolidine derivative and novel… Expand
Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin‐1‐induced contraction in human bronchi
- T. Fukuroda, S. Ozaki, +7 authors M. Nishikibe
- Chemistry, Medicine
- British journal of pharmacology
- 1 March 1996
1 Endothelin (ET)‐1 has been postulated to be involved in the development of obstructive airway diseases in man. In the present study, we attempted to characterize ET receptor subtypes mediating… Expand
Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes.
There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating… Expand
Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats.
The present study was undertaken to determine whether a non-peptide arginine vasopressin (AVP) antagonist [5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra hydro-1H- benzazepine]… Expand
Increases in interleukin-6 and matrix metalloproteinase-9 in the infarct-related coronary artery of acute myocardial infarction.
- H. Funayama, S. Ishikawa, +4 authors M. Kawakami
- Circulation journal : official journal of the…
- 20 April 2004
BACKGROUND To elucidate the involvement of inflammation in coronary artery occlusion, the regional changes in cytokines and matrix metalloproteinases (MMPs) in the infarct-related coronary artery… Expand
Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng).
- Pham Gia Tien, F. Kayama, +7 authors M. Kawakami
- Medicine, Biology
- International journal of oncology
- 1 April 2005
The antitumor activity of the crude water extract from Gac fruit (Momordica cochinchinensis) was investigated in vivo and in vitro. A water extract prepared from 0.75 and 0.25 mg dry weight of Gac… Expand
Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats.
The present study was undertaken to determine whether the non-peptide V2 antidiuretic hormone (ADH) antagonist 5-dimethylamino-1[4-(2- methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine… Expand
Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats.
Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats. Isolated glucocorticoid and mineralocorticoid deficiency have been known to… Expand
Association of Hyperadiponectinemia With Severity of Ventricular Dysfunction in Congestive Heart Failure
Background Adiponectin, which is a collagen-like plasma protein produced by adipose tissue, has anti-atherogenic and anti-inflammatory effects. Plasma adiponectin levels in patients with congestive… Expand