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Predicting the clinical status of human breast cancer by using gene expression profiles
- M. West, C. Blanchette, +7 authors J. Nevins
- Biology, MedicineProceedings of the National Academy of Sciences…
- 18 September 2001
Bayesian regression models that provide predictive capability based on gene expression data derived from DNA microarray analysis of a series of primary breast cancer samples are developed and the utility and validity of such models in predicting the status of tumors in crossvalidation determinations are assessed.
Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis
- S. Ishida, E. Huang, +4 authors J. Nevins
- Medicine, BiologyMolecular and Cellular Biology
- 15 July 2001
High-density DNA microarrays used to provide an analysis of gene regulation during the mammalian cell cycle and the role of E2F in this process identified genes or expressed sequence tags not previously described as regulated by E1F proteins; surprisingly, many of these encode proteins known to function during mitosis.
Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver.
- H. Jinno, T. Tanaka-Kagawa, +9 authors J. Sawada
- Biology, MedicineMolecular pharmacology
- 1 March 2004
Four novel splice variants in the ligand-binding domain (LBD) of hCAR were found and it was revealed that the hepatic expression of SV2 was almost comparable with that of SV0 (approximately 40%), whereas other variants accounted for 6 to 10% of the total hCAR transcripts.
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
It is proposed that E2F3 activity plays an important role during the cell cycle of proliferating cells, controlling the expression of genes whose products are rate limiting for initiation of DNA replication, thereby imparting a more dramatic control of entry into S phase than would otherwise be achieved by post-transcriptional control alone.
Loss of E2F4 activity leads to abnormal development of multiple cellular lineages.
Analysis of newborn pups deficient in E2F4 revealed abnormalities in hematopoietic lineage development as well as defects in the development of the gut epithelium, suggesting a critical role for E2f4 activity in controlling the maturation of cells in a number of tissues.
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.
It is reported that simultaneous inactivation of E 2F4 and E2F5 in mice results in neonatal lethality, suggesting that they perform overlapping functions during mouse development.
Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins
- G. Leone, F. Nuckolls, +5 authors J. Nevins
- Biology, MedicineMolecular and Cellular Biology
- 15 May 2000
A novel E2F product that specifically interacts with Rb in quiescent cells is described, which is encoded by a unique mRNA transcribed from an intronic promoter within the E 2F3 locus.
Gene expression phenotypic models that predict the activity of oncogenic pathways
This paper presents a meta-analyses of the determinants of infectious disease in eight operation theatres of the central nervous system using a model derived from the model developed in [Bouchut-Boyaval, M3].
Cytoprotection against oxidative stress‐induced damage of astrocytes by extracellular ATP via P2Y1 receptors
- Youichi Shinozaki, S. Koizumi, S. Ishida, J. Sawada, Y. Ohno, Kazuhide Inoue
- Biology, MedicineGlia
- 15 January 2005
It is reported that ATP but not adenosine protects against the cell death of cultured astrocytes induced by hydrogen peroxide (H2O2), and ATPinduced protection was inhibited by cycloheximide, a protein synthesis inhibitor, and it took more than 12 h for the onset of the protective action.
Distinct gene expression phenotypes of cells lacking Rb and Rb family members.
DNA microarray analysis is used to identify gene expression phenotypes that characterize the loss of Rb function, that distinguish a Rb-null cell from a wild-type cell as well as a p107/p130- null cell, and that identify gene regulatory pathways unique to these events.