A clinical approach to diagnosis of autoimmune encephalitis
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia
The identification of leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 as the major targets of potassium channel antibodies, and their associations with different clinical features, begins to explain the diversity of these syndromes.
Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
To describe a distinctive seizure semiology that closely associates with voltage‐gated potassium channel (VGKC)‐complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE).
Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study.
N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes
Overall, the data support a model in which the early features of N-methyl-d-aspartate receptor encephalopathy are associated with cerebrospinal fluid lymphocytosis, and the later features with appearance of oligoclonal bands, which is associated with restriction to the first stage.
Autoantibodies associated with diseases of the CNS: new developments and future challenges
Morvan syndrome: Clinical and serological observations in 29 cases
A study was undertaken to describe the clinical spectrum, voltage‐gated potassium channel (VGKC) complex antibody specificities, and central nervous system localization of antibody binding in 29…
Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype.
- S. Irani, C. Stagg, Michael R. Johnson
- Medicine, PsychologyBrain : a journal of neurology
- 1 October 2013
In conclusion, faciobrachial dystonic seizures can be prospectively identified as a form of epilepsy with an expanding phenotype and immunotherapy is associated with excellent control of the frequently anti-epileptic drug refractory seizures, hastens time to recovery, and may prevent the subsequent development of cognitive impairment observed in this study.
Disease-relevant autoantibodies in first episode schizophrenia
These cases were hypothesized that these antibodies would be present in a proportion of patients with early schizophrenia, in the absence of overt seizures, movement disorders, or other neurological signs, and the autoantibody positive cases fulfilled criteria for DSM-IV schizophrenia.