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Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia
TLDR
Notch signaling deregulation is linked to the onset of several tumors including T-cell acute lymphoblastic leukemia (T-ALL) and miRNAs regulated by Notch pathway are identified, including miR-223, whose putative promoter analysis revealed a conserved RBPjk binding site, which was nested to an NF-kB consensus. Expand
Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation
TLDR
The metabolic profile of cancer stem cells isolated from patients with epithelial ovarian cancer showed higher mitochondrial reactive oxygen species (ROS) production and elevated membrane potential, and underwent apoptosis upon inhibition of the mitochondrial respiratory chain. Expand
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
TLDR
Results establish the selective binding of a member of the pentraxin superfamily to a growth factor, which may modulate angiogenesis in various physiopathologic conditions driven by inflammation, innate immunity, and/or neoplastic transformation. Expand
An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia.
TLDR
A role is proposed for the alternative splicing of CD79b gene in causing the reduced expression of BCR on the surface of B-CLL cells, and the mechanism ofCD79b posttranscriptional regulation might reflect the activation stage of the normal B cell from which B- CLL derives. Expand
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.
TLDR
It is demonstrated that loss of PTEN and consequent AKT1 activation can effectively block glucocorticoid-induced apoptosis and induce resistance to glucoc Corticoid therapy, and pharmacologic inhibition of AKT with MK2206 effectively reverses glucocORTicoid resistance. Expand
Retroviral vectors for high-level transgene expression in T lymphocytes.
TLDR
MP71 vectors are useful tools for stable, high-level gene expression in T lymphocytes, for example, in the expression of T cell receptor genes. Expand
Identification of Genes Selectively Regulated by IFNs in Endothelial Cells1
TLDR
Findings improve the understanding of the antiangiogenic effects of IFNs by showing that these cytokines trigger an antiANGiogenic transcriptional program in EC, and suggest that quantitative differences in the magnitude of the transcriptional activation of IFN-responsive genes could form the basis for cell-specific transcriptional signatures. Expand
Hypoxia and HIF1α Repress the Differentiative Effects of BMPs in High‐Grade Glioma
TLDR
A novel, mutually antagonistic interaction of hypoxia‐response and neural differentiation signals in HGG proliferation is shown, and differences between normal and HGG precursors are suggested that may be exploited for pediatric brain cancer therapy. Expand
Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts
TLDR
T-acute lymphoblastic leukemia is characterized by several genetic alterations and poor prognosis in about 20–25% of patients, and serial transplantation experiments suggested that anti-Notch1 therapy could compromise leukemia-initiating cell functions. Expand
M30 Neoepitope Expression in Epithelial Cancer: Quantification of Apoptosis in Circulating Tumor Cells by CellSearch Analysis
TLDR
The M30-integrated test has potential for monitoring dynamic changes in the quote of apoptotic CTC (in addition to CTC count) to evaluate response in clinical trials of molecularly targeted anticancer therapeutics as well as for translational research, in which there is a pressing need for informative circulating biomarkers. Expand
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