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Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
It is suggested that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery. Expand
How individual sensitivity to opiates can be predicted by gene analyses.
Rapid advances in this research field are leading to improved understanding of the relationships between gene polymorphisms and opiate sensitivities that will enable more-accurate prediction of the opiate sensitivity and opiates requirements in individual patients. Expand
Mu opioid receptor-dependent and independent components in effects of tramadol
The results strongly support the idea suggested in the previous pharmacological studies that MOP and the adrenaline alpha2 receptor mediate most of the analgesic properties of tramadol. Expand
Pharmacological properties of TRK-820 on cloned μ-, δ- and κ-opioid receptors and nociceptin receptor
We analyzed the pharmacological properties of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride (TRK-820) using Chinese hamster ovaryExpand
Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms
The results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis. Expand
Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference
The results suggest that cholinergic transmission from the laterodorsal tegmental nucleus to the VTA is critically involved in both acquiring and retrieving cocaine-associated memories in cocaine CPP. Expand
Opposing Roles of Corticotropin-Releasing Factor and Neuropeptide Y within the Dorsolateral Bed Nucleus of the Stria Terminalis in the Negative Affective Component of Pain in Rats
Some of the neuronal mechanisms underlying the affective component of pain are uncovered by showing opposing roles of intra-dlBNST CRF and NPY in pain-induced aversion and opposing actions of these peptides on neuronal excitability converging on the same target, type II neurons, within the dlBNST. Expand
Study of Association between α‐Synuclein Gene Polymorphism and Methamphetamine Psychosis/Dependence
An association of the α‐synuclein gene polymorphisms with MAP psychosis/dependence in female subjects is suggested, although further analyses are necessary to clarify the gender difference, by using a larger sample size and/or different ethnic groups, as well as functional variations in theα‐syn nuclein gene. Expand
Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice
The results suggest that social stress that is caused by a deficit in social recognition desensitizes 5‐HT2c receptors, followed by an anhedonic‐ and depressive‐like state, in GluN2D KO mice. Expand
Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.
Results indicate that TRK-820 acts as a full agonist for the kappa-opioid receptor, a partial agonists for the mu-opIOid receptor and a low-affinity antagonist for the nociceptin receptor. Expand