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Analgesic effect of morphine glucuronides.
Pharmacological properties of morphine-3-glucuronide and morphine-6-glucuronide were studied in mice and compared with those of morphine. 1) The analgesic effect of morphine-6-glucuronide was 3 to 4Expand
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Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats.
Abstract To understand the potent analgesic action of morphine-6-glucuronide (M-6-G), which was reported previously to be a minor metabolite of morphine in several mammalian species, the penetrationExpand
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Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype.
The combined deficiency of thyrotropin, growth hormone and prolactin, caused by PIT1 abnormality manifests in the homozygous or heterozygous state. We studied a patient having an allele withExpand
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Mast cells in bronchoalveolar lumen of patients with bronchial asthma.
Bronchoalveolar lavage was performed on patients with stable bronchial asthma to elucidate the existence and significance of mast cells in human bronchoalveolar lumen. The percentage of total mastExpand
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Excretion of porphyrins in urine and bile after the administration of delta-aminolevulinic acid.
Excretion of porphyrins into bile and urine after intravenous injection of delta-ALA was studied in three patients with catheters inserted into the bile duct because of biliary obstruction and in twoExpand
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Specificity of anti-nuclear antibodies induced in F1 mice undergoing the graft-vs-host reaction: isotypes and cross-reactivities.
(C57BL/6 X DBA/2)F1 mice undergoing the graft-vs-host reaction (GVHR) produce autoantibodies after the injection of DBA/2 lymphoid cells. The anti-nuclear antibodies, including anti-poly (ADP-ribose)Expand
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Metabolism of drugs. LXIX. Studies on the urinary metabolites of morphine in several mammlian species.
In the previous study of this series, morphine was shown to be metabolized not only to morphine-3-glucuronide, but also to morphine-6-glucuronide in rabbits. The present study have demonstrated thatExpand
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Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells.
Macrolide antibiotics have clinical benefits in patients with diffuse panbronchiolitis and in patients with cystic fibrosis. Although many mechanisms have been proposed, the precise mechanisms areExpand
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In vivo antiviral effects of mismatched double‐stranded RNA on duck hepatitis B virus
The antiviral activity and ability of mismatched double‐stranded RNA (m‐dsRNA), r(I)n′r(C12‐U)n′ to induce interferon (IFN) were evaluated in ducks chronically infected with duck hepatitis B virusExpand
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Effects of Lithium on the Pharmacokinetics of Valproate in Rats
Combined treatment with lithium and valproate has been used for bipolar disorder. However, the studied interaction between these two drugs has not been fully investigated. We therefore examined theExpand
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