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Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins
Analysis of cell cycle regulation in the budding yeast Saccharomyces cerevisiae has shown that a central regulatory protein kinase, Cdc28, undergoes changes in activity through the cell cycle byExpand
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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1–S phase transition and is thought to be critical for the initiation of DNA replication and other S-phaseExpand
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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor. After induction of theseExpand
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Physical interaction of the retinoblastoma protein with human D cyclins
The retinoblastoma protein (pRb) functions as a regulator of cell proliferation and in turn is regulated by cyclin-dependent kinases. Cyclins D1 and D3 can form complexes with pRb that resemble thoseExpand
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Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.
We have isolated STN1, an essential Saccharomyces cerevisiae gene, as a suppressor of the cdc13-1 mutation. A synthetic lethal interaction between a temperature-sensitive mutant allele of STN1,Expand
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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
gamma-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell cycle prior to S phase. This cell cycle block was correlated with a lack of activation of both cyclinExpand
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Association of human cyclin E with a periodic G1-S phase protein kinase.
G1 cyclins control the G1 to S phase transition in the budding yeast, Saccharomyces cerevisiae. Cyclin E was discovered in the course of a screen for human complementary DNAs that rescue a deficiencyExpand
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FBXW7/hCDC4 is a general tumor suppressor in human cancer.
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins,Expand
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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
The Cks/Suc1 proteins associate with CDK/cyclin complexes, but their precise function(s) is not well defined. Here we demonstrate that Cks1 directs the ubiquitin-mediated proteolysis of the CDK-boundExpand
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A family of cyclin homologs that control the G1 phase in yeast.
Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control ofExpand
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