Phytochemistry and Pharmacology of Genus Indigofera: A Review
- T. Rahman, M. Zeb, W. Liaqat, M. Sajid, S. Hussain, M. Choudhary
- Biology
- 7 September 2017
The metabolites and crude extracts of the genus indigofera were found to exhibit various bioactivities including, antimicrobial, insecticidal, phytotoxic, antiulcergenic, hepatot toxic, teratogenic and cytotoxicity.
Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis
- S. Hussain, M. Slevin, J. Gaffney
- Biology, ChemistryAngiogenesis
- 11 March 2008
Investigation of the anti-angiogenic potential of two naturally occurring sesterterpenes isolated from the Himalayan plant Leucosceptrum canum concludes that these compounds may have potential as anti-tumour agents.
Phosphodiesterase and thymidine phosphorylase-inhibiting salirepin derivatives from Symplocos racemosa.
- M. Abbasi, V. Ahmad, M. Choudhary
- Chemistry, BiologyPlanta Medica
- 1 December 2004
A re-investigation of the chemical constituents of the stem bark of Symplocos racemosa Roxb led to the isolation of four new glycosides, symplocomoside (1, symponoside), symplososide and symploveroside, which were determined by 1D and 2D-homonuclear and heteronuclear NMR spectroscopy, chemical evidence, and by comparison with the published data of the closely related compounds.
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.
- K. Khan, N. Ambreen, S. Hussain, S. Perveen, M. Choudhary
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 April 2009
Novel sesterterpenes from Leucosceptrum canum of nepalese origin.
- M. Choudhary, R. Ranjit, M. Parvez
- ChemistryOrganic Letters
- 16 October 2004
Two novel sesterterpenoids with novel skeleta isolated from the hexane extract of the medicinal plant, Leucosceptrum canum, were found to exhibit activity against prolylendopeptidase (PEP).
Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis
- S. Hussain, M. Slevin, J. Gaffney
- Biology, ChemistryBMC Cell Biology
- 23 April 2009
Investigation of the anti-angiogenic potential of two naturally occurring stilbene glycosides isolated from the medicinal plant Boswellia papyriferai found compound 1 inhibited FGF-2 induced angiogenesis by binding to its cognate receptors and is an addition to the small number of natural product inhibitors of angiogenic processes.
2,5-Disubstituted-1,3,4-oxadiazoles: thymidine phosphorylase inhibitors
- K. Khan, M. Rani, M. Choudhary
- Chemistry, BiologyMedicinal Chemistry Research
- 21 April 2013
A series of 2,5-disubstituted-1,3,4-oxadiazoles synthesized via microwave irradiation and screened against thymidine phosphorylase enzyme exhibited an enhanced inhibitory potential, while phenyl analogs did not show substantial inhibitory Potential.
3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors
- K. Khan, S. Ahmed, S. Hussain, N. Ambreen, S. Perveen, M. Choudhary
- Chemistry
- 1 May 2010
Biotransformation of (-)-ambrox by cell suspension cultures of Actinidia deliciosa.
- A. Nasib, S. Musharraf, M. Choudhary
- Biology, ChemistryJournal of Natural Products
- 2 June 2006
Biotransformation of (-)-ambrox with cell suspension cultures of Actinidia deliciosa (Kiwifruit) yielded the regio- and stereospecific oxygenated products 3-oxoambrox, which were found to be new compounds.
Cheiradone: a vascular endothelial cell growth factor receptor antagonist
- S. Hussain, M. Slevin, J. Gaffney
- Biology, MedicineBMC Cell Biology
- 29 January 2008
Cheiradone inhibited V EGF-induced angiogenesis by binding to VEGF receptors -1 and -2 and may be a useful investigative tool to study the specific contribution of VEGf to angiogenic and may have therapeutic potential.
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