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- Publications
- Influence
Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.
- E. Nutku, H. Aizawa, S. Hudson, B. Bochner
- Biology, Medicine
- Blood
- 15 June 2003
Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8), which exists in 2 isoforms including one possessing cytoplasmic tyrosine motifs, is expressed only on human eosinophils, basophils, and… Expand
Activation of Human Leukocytes Reduces Surface P-Selectin Glycoprotein Ligand-1 (PSGL-1, CD162) and Adhesion to P-Selectin In Vitro1
- K. L. Davenpeck, M. Brummet, S. Hudson, R. Mayer, B. Bochner
- Biology, Medicine
- The Journal of Immunology
- 1 September 2000
P-selectin glycoprotein ligand-1 (PSGL-1), the primary ligand for P-selectin, is constitutively expressed on the surface of circulating leukocytes. The objective of this study was to examine the… Expand
Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.
- H. Yokoi, O. H. Choi, +9 authors B. Bochner
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 February 2008
BACKGROUND
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on human eosinophils,… Expand
Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.
- E. Nutku, S. Hudson, B. Bochner
- Biology, Medicine
- Biochemical and biophysical research…
- 28 October 2005
Sialic acid binding immunoglobulin like lectin (Siglec)-8 crosslinking with specific antibodies causes human eosinophil apoptosis. Mechanisms by which Siglec-8 crosslinking induces apoptosis are not… Expand
Siglec‐F antibody administration to mice selectively reduces blood and tissue eosinophils
- N. Zimmermann, M. McBride, +6 authors B. Bochner
- Biology, Medicine
- Allergy
- 1 September 2008
Background: Sialic acid‐binding immunoglobulin‐like lectins (Siglecs) are a family of receptors that bind sialic acid and mostly contain immunoreceptor tyrosine‐based inhibitory motifs, suggesting… Expand
IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.
- H. Na, S. Hudson, B. Bochner
- Biology, Medicine
- Cytokine
- 2012
IL-33 activates eosinophils directly via the ST2 receptor. Like IL-5, IL-33 induces eosinophilia and eosinophilic airway inflammation in mouse models and primes human eosinophil responses.… Expand
Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
- Takumi Kiwamoto, T. Katoh, +6 authors B. Bochner
- Chemistry, Medicine
- The Journal of allergy and clinical immunology
- 1 May 2015
BACKGROUND
Sialic acid-binding, immunoglobulin-like lectin (Siglec) F is a glycan-binding protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis, suggesting a pathway… Expand
Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen
- Hui Mao, G. Kano, +4 authors B. Bochner
- Biology, Medicine
- PloS one
- 28 June 2013
Background Siglec-F and Siglec-8 are functional paralog proapoptotic cell surface receptors expressed on mouse and human eosinophils, respectively. Whereas Siglec-8 mediated death involves caspases… Expand
Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation.
- H. Tachimoto, S. Hudson, B. Bochner
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 February 2001
BACKGROUND
Mature human mast cells express several types of adhesion molecules on their surface. Interactions between extracellular matrix (ECM) and adhesion molecules may be important for the… Expand
Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways.
- Esra Nutku-Bilir, S. Hudson, B. Bochner
- Biology, Medicine
- American journal of respiratory cell and…
- 2008
Previously, we have identified the sequential activation of reactive oxygen species (ROS), mitochondria, and caspase-3, -8, and -9, in Siglec-8-mediated eosinophil apoptosis. Cytokine priming, which… Expand