• Publications
  • Influence
Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.
Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8), which exists in 2 isoforms including one possessing cytoplasmic tyrosine motifs, is expressed only on human eosinophils, basophils, andExpand
  • 267
  • 8
  • PDF
Activation of Human Leukocytes Reduces Surface P-Selectin Glycoprotein Ligand-1 (PSGL-1, CD162) and Adhesion to P-Selectin In Vitro1
P-selectin glycoprotein ligand-1 (PSGL-1), the primary ligand for P-selectin, is constitutively expressed on the surface of circulating leukocytes. The objective of this study was to examine theExpand
  • 117
  • 8
Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.
BACKGROUND Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on human eosinophils,Expand
  • 105
  • 4
Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.
Sialic acid binding immunoglobulin like lectin (Siglec)-8 crosslinking with specific antibodies causes human eosinophil apoptosis. Mechanisms by which Siglec-8 crosslinking induces apoptosis are notExpand
  • 92
  • 2
Siglec‐F antibody administration to mice selectively reduces blood and tissue eosinophils
Background:  Sialic acid‐binding immunoglobulin‐like lectins (Siglecs) are a family of receptors that bind sialic acid and mostly contain immunoreceptor tyrosine‐based inhibitory motifs, suggestingExpand
  • 112
  • 2
IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.
IL-33 activates eosinophils directly via the ST2 receptor. Like IL-5, IL-33 induces eosinophilia and eosinophilic airway inflammation in mouse models and primes human eosinophil responses.Expand
  • 52
  • 2
Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
BACKGROUND Sialic acid-binding, immunoglobulin-like lectin (Siglec) F is a glycan-binding protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis, suggesting a pathwayExpand
  • 50
  • 2
Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen
Background Siglec-F and Siglec-8 are functional paralog proapoptotic cell surface receptors expressed on mouse and human eosinophils, respectively. Whereas Siglec-8 mediated death involves caspasesExpand
  • 30
  • 1
  • PDF
Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation.
BACKGROUND Mature human mast cells express several types of adhesion molecules on their surface. Interactions between extracellular matrix (ECM) and adhesion molecules may be important for theExpand
  • 32
  • 1
Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways.
Previously, we have identified the sequential activation of reactive oxygen species (ROS), mitochondria, and caspase-3, -8, and -9, in Siglec-8-mediated eosinophil apoptosis. Cytokine priming, whichExpand
  • 63