• Publications
  • Influence
Advances and Challenges of Liposome Assisted Drug Delivery
TLDR
The advances in liposome assisted drug delivery, biological challenges that still remain, and current clinical and experimental use of liposomes for biomedical applications are discussed.
Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization
TLDR
Key issues related to the clinical development of NNMs will be covered, including biological challenges, large-scale manufacturing, biocompatibility and safety, intellectual property (IP), government regulations, and overall cost-effectiveness in comparison to current therapies.
Physiological and Pharmaceutical Considerations for Rectal Drug Formulations
  • S. Hua
  • Biology, Medicine
    Front. Pharmacol.
  • 16 October 2019
TLDR
This review will address the physiological and pharmaceutical considerations influencing rectal drug delivery as well as the conventional and novel drug delivery approaches.
Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration
  • S. Hua
  • Biology
    Front. Pharmacol.
  • 5 November 2019
TLDR
This review will focus on the physiological aspects that influence buccal andSublingual drug delivery and the advances in nanoparticulate drug delivery approaches for sublingual and buccals administration.
Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis
TLDR
This review will focus on the differential expression of HIFs within the synovial joint and its functional behavior in different cell types to regulate RA progression and potential development of new therapeutic strategies targeting HIF-regulated pathways at sites of disease in RA.
Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery
  • S. Hua
  • Medicine, Biology
    International journal of nanomedicine
  • 30 January 2014
TLDR
It is demonstrated that the actual method used for equilibrium dialysis plays a significant role in determining the true characteristics of a topical nanoformulation, with Method 3 providing the most accurate indication of the release of a hydrophobic drug from a topical liposomal formulation.
Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.
TLDR
Overall, exposure of VSMCs (either in cell culture or intact vessels) to pathological *NO promotes an up-regulation of the Mb gene and protein, suggesting a feedback relationship between *NO and Mb that regulates the concentration of the potent cell signalling molecule in the vessel wall, similar to the role haemoglobin plays in the vessels lumen.
Lipid-based nano-delivery systems for skin delivery of drugs and bioactives
  • S. Hua
  • Biology
    Front. Pharmacol.
  • 30 September 2015
TLDR
Novel topical drug delivery systems, with the use of nanotechnology in dosage form design, have been used to facilitate overcoming the skin barrier to increase drug absorption through the skin.
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