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A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
MITOCHONDRIAL encephalomyopathies are usually divided into three distinct clinical subgroups: (1) mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS); (2)Expand
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Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
We analyzed the complete mitochondrial DNA (mtDNA) sequences of three humans (African, European, and Japanese), three African apes (common and pygmy chimpanzees, and gorilla), and one orangutan in anExpand
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Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes
AbstractHistoric Japanese culture evolved from at least two distinct migrations that originated on the Asian continent. Hunter-gatherers arrived before land bridges were submerged after the lastExpand
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mtDNA polymorphism in East Asian Populations, with special reference to the peopling of Japan.
Nucleotide sequences of the major noncoding (D-loop) region of human mtDNA from five East Asian populations including mainland Japanese, Ainu, Ryukyuans, Koreans, and Chinese were analyzed. On theExpand
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Y chromosomal DNA variation and the peopling of Japan.
Four loci mapping to the nonrecombining portion of the Y chromosome were genotyped in Japanese populations from Okinawa, the southernmost island of Japan; Shizuoka and Aomori on the main island ofExpand
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The geographic distribution of human Y chromosome variation.
We examined variation on the nonrecombining portion of the human Y chromosome to investigate human evolution during the last 200,000 years. The Y-specific polymorphic sites included the Y AluExpand
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Molecular phylogeny of macaques: implications of nucleotide sequences from an 896-base pair region of mitochondrial DNA.
We determined the nucleotide sequences of an 896-base pair region of mitochondrial DNA (mtDNA) from 20 primates representing 13 species of macaques, a baboon, and a patas. We compared these sequencesExpand
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Molecular phylogeny and evolution of prosimians based on complete sequences of mitochondrial DNAs.
Prosimians (tarsiers and strepsirrhini) represent the basal lineages in primates and have a close bearing on the origin of primates. Although major lineages among anthropoidea (humans, apes andExpand
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Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS)
We studied 40 MELAS patients (21 male and 19 female) to characterize the clinical features and biochemical and muscle biopsy findings related to the mtDNA mutation at the nucleotide position ofExpand
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Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages
AbstractThe Ainu, a minority ethnic group from the northernmost island of Japan, was investigated for DNA polymorphisms both from maternal (mitochondrial DNA) and paternal (Y chromosome) lineagesExpand
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