• Publications
  • Influence
Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids.
Current investigations suggest that taxine alkaloids chief action is on cardiac myocytes resulting in heart failure and death in instances of animal and human poisoning. Expand
Toxicity of Microcystin LR, a Cyclic Heptapeptide Hepatotoxin from Microcystis aeruginosa, to Rats and Mice
Analysis of serum revealed an increase in alanine aminotransferase 40 min after toxin; at 6 to 12 hr there were significant increases in alkaline phosphatase, total bilirubin, blood urea nitrogen, and creatinine. Expand
All-trans-retinol alteration of 1-nitronaphthalene-induced pulmonary and hepatic injury by modulation of associated inflammatory responses in the male Sprague-Dawley rat.
In the lung pretreatment with retinol decreased the severity of 1-NN-induced toxicity apparently by an anti-inflammatory mechanism, and in the liver, ret inol potentiated 1-nn-induced liver injury apparently through a proinflammatory mechanism by activating Kupffer cells and increasing the infiltration of neutrophils into the periportal regions adjacent to bile ducts. Expand
Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides.
Results indicate that vinylcyclohexene diepoxide may be the ultimate ovotoxic metabolite of VCH, and may be linked to the ovarian toxicity and carcinogenicity of these olefins. Expand
Toxicity of intraperitoneal doses of microcystin-LR in two strains of male mice.
Male Balb/C and Swiss Webster (SW) mice were administered various i.p. doses of microcystin-LR (MCLR) to establish dose-response curves and to determine if a sublethal dose of MCLR would protectExpand
Fatal Ricin Toxicosis in a Puppy Confirmed by Liquid Chromatography/Mass Spectrometry when Using Ricinine as a Marker
This report describes a fatal case of castor bean ingestion in a 12-week-old Mastiff puppy, with confirmation of ricin exposure through detection of the biomarker ricinine by liquid chromatography/mass spectrometry (LC/MS). Expand
Toxicity of yew ( Taxus spp.) alkaloids
Improvements in analytical toxicology have made chemical confirmation of the taxine alkaloids in diagnostic cases possible, and the primary treatment for exposed mammals primarily involves symptomatic and supportive care. Expand
Actin Filament Alterations in Rat Hepatocytes Induced In Vivo and In Vitro by Microcystin-LR, a Hepatotoxin from the Blue-green Alga, Microcystis aeruginosa
It is suggested that early MCLR-induced morphologic changes occurring both in vivo and in vitro are due to alterations in hepatocyte actin filaments. Expand
Blue-green algae (Microcystis aeruginosa) hepatotoxicosis in dairy cows.
Twenty cows from a dairy herd developed clinical signs of anorexia, mental derangement, dehydration, recumbency, and ruminal atony after ingesting water containing blue-green algae, a potentially hepatotoxic algae, and 9 died. Expand
Consistent inhibition of peripheral cholinesterases by neurotoxins from the freshwater cyanobacterium Anabaena flos-aquae: Studies of ducks, swine, mice and a steer
Freshwater algal blooms associated with outbreaks of sudden death in ducks and swine were examined for cholinesterase (ChE)-inhibiting toxins as the possible cause of death. In both investigations,Expand