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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,Expand
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A single-cell-based model of tumor growth in vitro: monolayers and spheroids.
To what extent the growth dynamics of tumors is controlled by nutrients, biomechanical forces and other factors at different stages and in different environments is still largely unknown. Here weExpand
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Individual-based approaches to birth and death in avascu1ar tumors
The understanding of the principles and the dominant mechanisms underlying tumor growth is an essential precondition in order to optimize treatment strategies. Mathematical and computer-based modelsExpand
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Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
Only little is known about how cells coordinately behave to establish functional tissue structure and restore microarchitecture during regeneration. Research in this field is hampered by a lack ofExpand
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On the Role of Physics in the Growth and Pattern Formation of Multi-Cellular Systems: What can we Learn from Individual-Cell Based Models?
We demonstrate that many collective phenomena in multi-cellular systems can be explained by models in which cells, despite their complexity, are represented as simple particles which areExpand
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A cell-based simulation software for multi-cellular systems
CellSys is a modular software tool for efficient off-lattice simulation of growth and organization processes in multi-cellular systems in 2D and 3D. It implements an agent-based model thatExpand
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Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatoryExpand
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Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing
Abstract Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to which these alterations are cause or consequence of compromised organ function, and theExpand
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Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liverExpand
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Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.
BACKGROUND & AIMS Recently, spatial-temporal/metabolic mathematical models have been established that allow the simulation of metabolic processes in tissues. We applied these models to decipherExpand
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