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The effect of a keto acid-amino acid supplement to a restricted diet on the progression of chronic renal failure.
- W. Mitch, M. Walser, T. Steinman, S. Hill, S. Zeger, K. Tungsanga
- MedicineThe New England journal of medicine
- 6 September 1984
This regimen with a low-phosphorus diet containing 20 to 30 g of mixed-quality protein, supplemented by amino acids and their keto analogues must have slowed or halted the progression of renal insufficiency in a majority of cases, especially when treatment was initiated before creatinine had reached the level of 8 mg per deciliter.
Can renal replacement be deferred by a supplemented very low protein diet?
Patients with chronic renal failure who met these criteria on presentation or who reached these levels of severity during treatment were managed conservatively until RRT was judged necessary by their chosen dialysis or transplantation team, and it was concluded that further study of this approach is indicated.
Treatment of nephrotic adults with a supplemented, very low-protein diet.
Branched-chain-ketoacid metabolism in patients with chronic renal failure.
Branched-chain ketoacids (BCKAs) were determined in fasting plasma samples from 19 patients with chronic renal failure (CRF). Ketomethylvalerate (KMV) was significantly higher in patients receiving…
Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis.
- J. Coresh, M. Walser, S. Hill
- Medicine, BiologyJournal of the American Society of Nephrology…
- 1 November 1995
Monitoring patients treated with a very low-protein diet supplemented with either essential amino acids or a ketoacid-amino acid mixture indicates that protein restriction and close clinical monitoring predialysis does not worsen and may substantially improve survival during the first 2 yr on dialysis.
A crossover comparison of progression of chronic renal failure: ketoacids versus amino acids.
It is concluded that KA slow progression, relative to AA, independently of protein or phosphorus intake, in patients on this regimen is concluded.
Vessel wall heparan sulfate and transcapillary passage of albumin in experimental diabetes in the rat.
- J. van den Born, A. A. van Kraats, S. Hill, M. Bakker, J. Berden
- Biology, MedicineNephrology, dialysis, transplantation : official…
Data indicate that in one-year diabetic rats albuminuria coincides with an increased TERalb and RCalb in most, but not all tissues, and that alterations in basement membrane HS content correlate with changes in the R Calb, which suggests a functional relationship.
Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.
- S. Hill, V. Arutchelvam, R. Quinton
- Medicine, BiologyIDrugs : the investigational drugs journal
- 1 February 2009
Enclomiphene demonstrates promise in the management of secondary hypogonadism associated with obesity, metabolic syndrome and, possibly, infertility, and should undergo placebo-controlled, randomized clinical trials for these indications.
Free and protein-bound tryptophan in serum of untreated patients with chronic renal failure.
The serum level of free tryptophan is well-maintained in chronic renal failure, being uninfluenced by severity of renal insufficiency, voluntary protein intake, or serum protein concentrations.
Progression of chronic renal failure on substituting a ketoacid supplement for an amino acid supplement.
The results suggest that this ketoacid supplement slows progression by approximately half, compared with an essential amino acid supplement, with no change in diet.