S. Hestrin

Publications58
h-index39
Citations10,780
Highly Influential Citations765
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A network of fast-spiking cells in the neocortex connected by electrical synapses
TLDR
It is shown that communication through electrical synapses allows excitatory signalling among inhibitory cells and promotes their synchronous spiking, and establishes a network of fast-spiking cells in the neocortex which may play a key role in coordinating cortical activity.
Molecular and Physiological Diversity of Cortical Nonpyramidal Cells
TLDR
The results indicate that neocortical nonpyramidal neurons display a large diversity in their firing properties and biochemical patterns of co-expression and that both characteristics could be correlated to define discrete subpopulations.
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
TLDR
A representative group of researchers are convened to agree on a set of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex, and the resulting terminology might provide a stepping stone towards a future classification of these complex and heterogeneous cells.
Analysis of excitatory synaptic action in pyramidal cells using whole‐cell recording from rat hippocampal slices.
TLDR
These experiments provide a detailed description of the dual receptor mechanism operating at hippocampal excitatory synapses and an electrophysiological method for estimating the electrotonic distance of synaptic inputs.
Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex
TLDR
The results indicate that PV-FS cells are highly interconnected in the adult cerebral cortex by both electrical and chemical synapses, establishing networks that can have important implications for coordinating activity in cortical circuits.
Electrical synapses between Gaba-Releasing interneurons
TLDR
These studies indicate that electrical coupling is a fundamental feature of local inhibitory circuits and suggest that electrical synapses define functionally diverse networks of GABA-releasing interneurons.
Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse
TLDR
The duration of evoked NMDA-receptor-mediated excitatory postsynaptic currents in the superior colliculus is several times longer at early developmental stages compared to that measured in older animals, indicating that the molecular properties of NMDA receptors are developmentally regulated and thus may be controlling the ability of synapses to change in early life.
Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex
TLDR
It is reported that sustained activation by trains of several hundred presynaptic spikes resulted in much stronger depression of synaptic currents at excitatory synapses than at inhibitory ones, suggesting that inhibitory terminals of fast-spiking cells are better equipped to support prolonged transmitter release at a high frequency.
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices
TLDR
The present results support a model in which the rise time and decay of the NMDA component are determined primarily by slow channel kinetics and the Decay of the non-NMDA component is due either to channel Kinetics or to desensitization.
Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex
TLDR
Direct evidence is presented that the rate of onset of desensitization is much slower than the decay rate of the response to a brief application of glutamate, implying that the decay of mEPSCs reflects channel closure into a state readily available for reactivation.
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