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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising
Prevalence of Vitamin D Insufficiency in an Adult Normal Population
The results showed that in French normal adults living in an urban environment with a lack of direct exposure to sunshine, diet failed to provide an adequate amount of vitamin D, and the clinical utility of winter supplementation with low doses ofitamin D was discussed.
Variation in FTO contributes to childhood obesity and severe adult obesity
It is concluded that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
Common variants at 30 loci contribute to polygenic dyslipidemia
The results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.
Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies.
This meta-analysis of cohort studies shows that fruit and vegetable consumption is inversely associated with the risk of CHD, although the causal mechanism of this association remains to be demonstrated.
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.
It is demonstrated that MC4-R mutations are a frequent but heterogeneous genetic cause of morbid obesity and transmission in the families of the carriers indicates a variable expressivity that is not related to the functional severity of the mutations.
The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.
After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women, suggesting that supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene.
Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’
This study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.