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Properties of norepinephrine N-methyltransferase from rat, cat and chicken brain.
Kinetic properties of norepinephrine N-methyltransferase (NMT) in ammonium sulfate fractions from rat, cat and chicken brain seem to be qualitatively similar both in substrate kinetics and susceptibility to inhibitors.
Metabolic changes in rabbit articular cartilage due to inflammation.
The effect of inflammation on the articular cartilage of rabbit knee joints were studied and a significant change was observed in the type of collagen synthesized by these explants in vitro.
Effects of Fenfluramine and Norfenfluramine on Brain Serotonin Metabolism in Rats
- R. Fuller, H. Snoddy, S. Hemrick
- Chemistry, MedicineProceedings of the Society for Experimental…
- 1 February 1978
Serotonin turnover, as measured by the rate of 5-hydroxyindoleacetic acid accumulation after probenecid administration, was decreased significantly still at 1 week after fenfluramine administration.
Studies of noradrenergic influence on cardiac ornithine decarboxylase in rats.
- R. Fuller, S. Hemrick
- Chemistry, MedicineJournal of molecular and cellular cardiology
- 1 November 1978
Neither propranolol nor 6-hydroxydopamine significantly affected enzyme activity by themselves, suggesting that tonic noradrenergic input is not necessary for maintenance of basal ornithine decarboxylase activity in heart.
p-Iodoamphetamine as a serotonin depletor in rats.
Enhanced selectivity of pargyline as an inhibitor of type B monoamine oxidase in harmaline-treated rats.
In heart, inhibition of both phenylethylamine and serotonin oxidation by pargyline was prevented by harmaline; this finding supports other evidence that phenyleethylamine is metabolized by type A MAO in rat heart.
Inhibition of rat brain norepinephrine N-methyltransferase by 2,3,4,5-tetrahydro-1H-indeno [1,2-c]-pyridine hydrochloride (LY87130)
The ability of LY87130 to produce selective depletion of epinephrine in rat brain makes it a useful tool for manipulating epine dopamine-forming neurons.
Norepinephrine, monoamine oxidase, and acetylcholinesterase in the rat jugular vein compared with other blood vessels.
- M. Cohen, A. Landry, S. Hemrick, R. Fuller
- Chemistry, MedicineCanadian journal of physiology and pharmacology
- 1 November 1979
Evidence is provided that the inability to generate a response to field stimulation in the rat jugular vein results from the lack of functional innervation in this tissue, which adds to the usefulness of this preparation for comparative studies of agents acting on the smooth muscle without the added complication of neuronal uptake mechanisms.
Inhibition of monoamine oxidase by N-phenacyl-cyclopropylamine.
Abstract N -phenacyl-cyclopropylamine hydrobromide (54761) was evaluated in vitro and in vivo as a monoamine oxidase (MAO) inhibitor in rats. In contrast to 51641, which has an o-chlorophenoxy group…
Inhibition in vitro of rabbit adrenal norepinephrine N-methyltransferase by 2,3,4,5-tetrahydro-1H-2-benzazepines.