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Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
A circuit-based framework for understanding gene and neurotransmitter interactions in schizophrenia is developed and Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia. Expand
A large annotated medical image dataset for the development and evaluation of segmentation algorithms
A large, curated dataset representative of several highly variable segmentation tasks that was used in a crowd-sourced challenge - the Medical Segmentation Decathlon held during the 2018 Medical Image Computing and Computer Aided Interventions Conference in Granada, Spain. Expand
Thalamocortical dysconnectivity in schizophrenia.
The etiology of schizophrenia may disrupt the development of prefrontal-thalamic connectivity and refinement of somatomotor connectivity with the thalamus that occurs during brain maturation, establishing differential abnormalities of thalamocortical networks in schizophrenia. Expand
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
Poor attention and impaired memory are enduring and core features of schizophrenia. These impairments have been attributed either to global cortical dysfunction or to perturbations of specificExpand
Molecular evidence for mitochondrial dysfunction in bipolar disorder.
Findings point toward a widespread dysregulation of mitochondrial energy metabolism and downstream deficits of adenosine triphosphate-dependent processes in bipolar disorder. Expand
Definition and description of schizophrenia in the DSM-5
The essence of the broad DSM-IV definition of schizophrenia is retained and changes in its definition should improve diagnosis and characterization of individuals with schizophrenia and facilitate measurement-based treatment and concurrently provide a more useful platform for research that will elucidate its nature. Expand
Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
In schizophrenia, hippocampal and amygdala activity is elevated during the passive viewing of human faces, and this activity is measured relative to a low-level baseline (fixation) condition. Expand
Functional resting-state networks are differentially affected in schizophrenia
The results indicate that resting-state networks are differentially affected in schizophrenia, and the alterations are characterized by reduced segregation between the default mode and executive control networks in the prefrontal cortex and temporal lobe, and reduced connectivity in the dorsal attention andExecutive control networks. Expand
Hippocampal activation during transitive inference in humans
It is concluded that immediate access to simple stimulus‐stimulus relationships is mediated via the parahippocampal gyrus, whereas the flexible representation of memory requires the recruitment of the hippocampus. Expand
Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: evidence from PET.
Strategic memory is examined with PET and a verbal encoding paradigm to indicate that orbitofrontal cortex performs an important, and previously unappreciated, role in strategic memory by supporting the early mobilization of effective behavioural strategies in novel or ambiguous situations. Expand