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Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
- Jeffrey A. Smith, C. Poteet-Smith, Ya-ming Xu, T. Errington, S. Hecht, D. Lannigan
- BiologyCancer research
- 1 February 2005
It is shown that RSK has an unexpected role in proliferation of transformed cells and may be a useful new target for chemotherapeutic agents and SL0101 will provide a powerful new tool to dissect the molecular functions of RSK in cancer cells.
Structural Studies of
Bleomycin: new perspectives on the mechanism of action.
- S. Hecht
- ChemistryJournal of natural products
The bleomycin group antitumor antibiotics have long been of interest as a consequence of their efficacy in the treatment of certain tumors, not to mention their unique structures and properties in…
Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question
It is concluded that oxidative stress does constitute a major contributing factor to FRDA pathology and reaffirms the idea that the rational design of specific small molecule multifunctional antioxidants will benefit FRDA patients.
On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex.
Results are consistent with a model in which camptothecin reversibly traps an intermediate involved in DNA unwinding by topoisomerase I and thereby perturbs a set of equilibria, resulting in increased DNA cleavage.
Camptothecin: current perspectives.
Site-specific cleavage of RNA by Fe(II).bleomycin.
- B. J. Carter, E. de Vroom, E. Long, G. A. van der Marel, J. V. van Boom, S. Hecht
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1990
RNA cleavage was oxidative, approximately 10-fold more selective than DNA cleavage, and largely unaffected by nonsubstrate RNAs; subsets of nucleotides at the junction of single- and double-stranded regions were especially susceptible to cleavage.
Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase β by NMR Chemical Shift Mapping*
- Hong-Yu Hu, J. Horton, G. P. Mullen
- Biology, ChemistryJournal of Biological Chemistry
- 17 September 2004
NMR-based mapping techniques can be used in the design of small molecule enzyme inhibitors including those with potential use in a clinical setting, as illustrated by the results of β-pol null mouse fibroblasts.
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.
- N. Sonenberg, K. Rupprecht, S. Hecht, A. Shatkin
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1979
A 24,000-dalton polypeptide that binds strongly and can be specifically crosslinked to the 5'-terminal cap structure m7GpppN in eukaryotic mRNAs has been detected in protein synthesis initiation…
Construction of modified ribosomes for incorporation of D-amino acids into proteins.
To permit the incorporation of D-amino acids into proteins using in vitro protein-synthesizing systems, a strategy has been developed to prepare modified ribosomes containing alterations within the peptidyltransferase center and helix 89 of 23S rRNA.