• Publications
  • Influence
Tobacco smoke carcinogens and lung cancer.
  • S. Hecht
  • Medicine
  • Journal of the National Cancer Institute
  • 21 July 1999
The complexity of tobacco smoke leads to some confusion about the mechanisms by which it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens convincingly cause lungExpand
  • 1,745
  • 83
  • PDF
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
  • S. Hecht
  • Biology, Medicine
  • Chemical research in toxicology
  • 2 June 1998
  • 926
  • 64
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae and the microsomes containing P450 1B1 were used to examine the selectivity of this enzyme in the activation of aExpand
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  • 39
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Tobacco carcinogens, their biomarkers and tobacco-induced cancer
  • S. Hecht
  • Medicine
  • Nature Reviews Cancer
  • 1 October 2003
The devastating link between tobacco products and human cancers results from a powerful alliance of two factors — nicotine and carcinogens. Without either one of these, tobacco would be just anotherExpand
  • 818
  • 30
Smokeless tobacco and cancer.
Use of smokeless tobacco products is common worldwide, with increasing consumption in many countries. Although epidemiological data from the USA and Asia show a raised risk of oral cancer (overallExpand
  • 492
  • 30
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
It is estimated that cigarette smoking kills over 1 000 000 people each year by causing lung cancer as well as many other neoplasmas. p53 mutations are frequent in tobacco-related cancers and theExpand
  • 898
  • 22
DNA adduct formation from tobacco-specific N-nitrosamines.
  • S. Hecht
  • Chemistry, Medicine
  • Mutation research
  • 8 March 1999
Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas, and oral cavity inExpand
  • 329
  • 20
Tobacco carcinogens, their biomarkers and tobacco-induced cancer
  • S. Hecht
  • Biology
  • Nature Reviews Cancer
  • 2004
Nature Reviews Cancer 3, 733–744 (2003) There is an article (October 2002) associated with this correction. Please click here to view it. On page 740 of this article, it was inadvertently impliedExpand
  • 307
  • 20
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer.
  • S. Hecht
  • Chemistry, Medicine
  • Carcinogenesis
  • 1 June 2002
Measurement of human urinary carcinogen metabolites is a practical approach for obtaining important information about tobacco and cancer. This review presents currently available methods andExpand
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  • 19
  • PDF