• Publications
  • Influence
Tobacco smoke carcinogens and lung cancer.
  • S. Hecht
  • Medicine
  • Journal of the National Cancer Institute
  • 21 July 1999
TLDR
By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned. Expand
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
  • S. Hecht
  • Biology, Medicine
  • Chemical research in toxicology
  • 2 June 1998
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
TLDR
The selectivity of this enzyme in the activation of a variety of environmental carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002 or NM2009 tester strains was examined using the SOS response as an end point of DNA damage. Expand
Tobacco carcinogens, their biomarkers and tobacco-induced cancer
  • S. Hecht
  • Medicine
  • Nature Reviews Cancer
  • 1 October 2003
The devastating link between tobacco products and human cancers results from a powerful alliance of two factors — nicotine and carcinogens. Without either one of these, tobacco would be just anotherExpand
Smokeless tobacco and cancer.
TLDR
Use of smokeless tobacco products is common worldwide, with increasing consumption in many countries, and epidemiological data from the USA and Asia show a raised risk of oral cancer, but this is not confirmed in northern European studies. Expand
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
TLDR
The available data suggest that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations. Expand
DNA adduct formation from tobacco-specific N-nitrosamines.
  • S. Hecht
  • Chemistry, Medicine
  • Mutation research
  • 8 March 1999
TLDR
In laboratory animals, DNA adduct formation and carcinogenicity of tobacco-specific N-nitrosamines are closely correlated in many instances, and it is likely that similar relationships will hold in humans. Expand
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer.
  • S. Hecht
  • Chemistry, Medicine
  • Carcinogenesis
  • 1 June 2002
TLDR
Urinary carcinogen metabolite biomarkers will be critical components of future studies on tobacco and human cancer, particularly with respect to new tobacco products and strategies for harm reduction, the role of metabolic polymorphisms in cancer, and further evaluation of human carcinogen exposure from ETS. Expand
Tobacco carcinogens, their biomarkers and tobacco-induced cancer
  • S. Hecht
  • Medicine
  • Nature Reviews Cancer
  • 2004
TLDR
On page 740 of this article, it was inadvertently implied that the authors of references 103 and 104 were somehow linked to the tobacco industry. Expand
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