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Functional role of 64P, the candidate transmission-blocking vaccine antigen from the tick, Rhipicephalus appendiculatus.
TLDR
Early expression in tick salivary glands is consistent with previously published data that 64P is a cement protein, and contributes to its candidacy as a vaccine antigen, however, further studies are required to assess whether cross-reactivity with skin proteins may induce autoimmunity. Expand
Diversity of Coxiella-like and Francisella-like endosymbionts, and Rickettsia spp., Coxiella burnetii as pathogens in the tick populations of Slovakia, Central Europe.
TLDR
Coxiella-like and Francisella-like microorganisms were identified for the first time in Slovakia, they might be considered as a non-pathogenic endosymbiont of I. ricinus and H. inermis, and future investigations could aim to assess their role in these ticks. Expand
ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe
TLDR
ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission, to develop and evaluate anti-tick vaccines that may prevent multiple human tick-borne diseases. Expand
Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection
TLDR
It is demonstrated that Tudor-SN plays a role in tick RNAi pathway and feeding but no strong evidence for a roles in innate immune responses to pathogen infection was found. Expand
Non-viraemic transmission of tick-borne viruses.
TLDR
For TBEV at least, NVT is an important mechanism of virus maintenance in nature and offers explanations for some specific aspects of tick-borne virus ecology such as focal virus distribution and vector competency of particular tick species. Expand
Clinical infection of Cantabrian chamois (Rupicapra pyrenaica parva) by louping ill virus: new concern for mountain ungulate conservation?
TLDR
This work describes the first association between LIV and clinical encephalitis in chamois, which suggests that special attention should be paid to the impact onChamois conservation and management in Asturias, and perhaps in other European regions. Expand
Immunization with recombinant subolesin does not reduce tick infection with tick-borne encephalitis virus nor protect mice against disease.
TLDR
It is shown that SUB expression is downregulated during Ixodes ricinus tick feeding but induced in ticks infected with TBEV, thus supporting a role for this molecule in tick innate immune response to virus infection and supporting the characterization of tick-pathogen interactions. Expand
Tick-Borne Encephalitis Virus Structural Proteins Are the Primary Viral Determinants of Non-Viraemic Transmission between Ticks whereas Non-Structural Proteins Affect Cytotoxicity
TLDR
Using laboratory-bred I. ricinus ticks, low and high efficiency NVT are demonstrated for TBEV strains Vasilchenko (Vs) and Hypr, respectively, indicating that the virion structural proteins largely determine T BEV NVT transmission efficiency between ticks. Expand
IrML — A Gene Encoding a New Member of the ML Protein Family from the Hard Tick, Ixodes ricinus
TLDR
Analysis of the predicted structure of I. ricinus ML-domain containing protein and its localization in the tick body could suggest that IrML is a secreted protein and is possibly involved in tick innate immunity. Expand
the role of the struCtural proteins in the non-viraemiC transmission of ti C k-borne en C ephalitis virus
TLDR
It is claimed that 3 out of 4 people infected with Flavivirus believe that the virus is caused byenza, while the rest believe that it is a result of natural causes. Expand
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