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A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different… Expand
[6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS
DNA isolated from macronuclei of the ciliate, Tetrahymena pyriformis, has been found to contain [6N]methyl adenine (MeAde); this represents the first clear demonstration of significant amounts of… Expand
Comparative study of DNA methylation in three unicellular eucaryotes.
We have analyzed the nature/content of methylated bases in the nuclear DNA of three unicellular eucaryotes. The pattern of methylation was different for each of the three organisms studied:… Expand
Transition from Nonspecific to Specific DNA Interactions along the Substrate-Recognition Pathway of Dam Methyltransferase
DNA methyltransferases methylate target bases within specific nucleotide sequences. Three structures are described for bacteriophage T4 DNA-adenine methyltransferase (T4Dam) in ternary complexes with… Expand
Sequence specificity of the P1 modification methylase (M.Eco P1) and the DNA methylase (M.Eco dam) controlled by the Escherichia coli dam gene.
Abstract Labeled oligonucleotides have been fractionated from pancreatic DNase digests of DNA that had been methylated in vitro with the P1 modification enzyme (M· Eco P1) or with the DNA-adenine… Expand
Unusual transcriptional and translational regulation of the bacteriophage Mu mom operon.
- S. Hattman
- Biology, Medicine
- Pharmacology & therapeutics
- 1 December 1999
The bacteriophage Mu mom gene encodes a novel DNA modification that protects the viral genome against a wide variety of restriction endonucleases. Expression of mom is subject to a series of unusual… Expand
5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA.
- J. Proffitt, J. Davie, D. Swinton, S. Hattman
- Biology, Medicine
- Molecular and cellular biology
- 1 May 1984
We examined the DNA of Saccharomyces cerevisiae by both HpaII-MspI restriction enzyme digestion and high-performance liquid chromatography analysis for the possible presence of 5-methylcytosine. Both… Expand
Interaction of the bacteriophage Mu transcriptional activator protein, C, with its target site in the mom promoter.
The bacteriophage Mu C gene encodes a 16.5 kDa site-specific DNA binding protein that is a transcriptional activator of the four "late" promoters, Pmom, Plys, PI and PP. A symmetrical consensus C… Expand
Deoxyribonucleic acid methylation and chromatin organization in Tetrahymena thermophila.
Deoxyribonucleic acid (DNA) of the transcriptionally active macronucleus of Tetrahymena thermophila is methylated at the N6 position of adenine to produce methyladenine (MeAde); approximately 1 in… Expand
In vitro transcriptional activation of the phage Mu mom promoter by C protein.
The phage Mu gene C encodes a 16.5-kDa site-specific DNA-binding protein that functions as a trans-activator of the four phage "late" operons, including mom. We have overexpressed and purified C and… Expand